Disorders - depressive disorders
Xia, H. S., Li, Y. X., Zhang, Q. Y., Zhong, D. L., Liu, X. B., Gou, X. Y., Fan,
J., Zhao, J., Zhang, Y., Ai, S. C., Huang, J. X., Li, J., Jin, R. J.
Background: Depression is a mental health disorder
characterized by affective, somatic, and cognitive symptoms. Attention bias modification (ABM) has been widely used to treat depression. However, the
results seem inconsistent. We conducted a systematic review and meta-analysis to investigate the efficacy of ABM for depression and to explore the
optimal protocol of ABM.\rMethods: Seven databases were systematically searched from their inceptions to 5 October 2022 to include randomized
controlled trials (RCTs) of ABM for depression. Two independent reviewers selected the eligible articles, extracted data, and evaluated the risk of
bias using version 2 of the Cochrane risk-of-bias tool (ROB 2.0) for randomized trials. The primary outcome was the evaluation of depressive symptoms
using widely accepted and validated scales. The secondary outcomes included rumination and attentional control. Meta-analysis was conducted by using
RevMan (version 5.4) and Stata (version 12.0). Subgroup analyses and meta-regressions were performed to identify the source of heterogeneity. The
certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE).\rResults: A total of 19
trials involving 20 datasets (1,262 participants) were included. The overall risk of bias in one study was rated as low risk of bias, three studies
were considered as high, and the remaining studies were some concerns. Compared with attention control training (ACT), ABM had a greater effect in
the improvement of depression (SMD = -0.48, 95% CI -0.80 to -0.17, I2 = 82%) and rumination (MD = -3.46, 95% CI -6.06 to -0.87,
I2 = 0%). No significant differences were observed in the attentional control outcome between ABM and ACT (MD = 3.07, 95% CI -0.52 to
6.65, I 2 = 0%). Subgroup analysis demonstrated that adults exhibited a greater decrease in depression scores than adolescents. ABM using
the dot-probe task, training target stimulus presented by face, and training directions by left-right were associated with better antidepressant
effects. ABM training delivered in the laboratory tended to yield a better effect than those conducted at home. Sensitivity analysis indicated that
the results were robust. The certainty of the evidence for all outcomes was low or very low, and publication bias may exist.\rConclusion: Due to high
heterogeneity and limited studies, not enough current evidence supported that ABM could be an effective intervention to relieve depressive symptoms.
More rigorous RCTs are required to verify the benefits and to explore the optimal protocol of ABM training for depression. Systematic Review
Registration: [PROSPERO], identifier [No. CRD42021279163].
Frontiers in
Psychiatry, 14 : 1098610
- Year: 2023
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Attention/cognitive bias
modification
Wuthrich, V.
M., Zagic, D., Dickson, S. J., McLellan, L. F., Chen, J. T., Jones, M. P., Rapee, R. M.
This systematic review and meta-analysis aimed to
examine the effectiveness of psychological interventions for internalising disorders in youth when delivered in routine settings. Secondary aims were
to examine the effectiveness of cognitive behavioural therapy and determine moderators of treatment response. The study was pre-registered (PROSPERO
2020 CRD42020202776). Databases were systematically searched (PsycINFO, Medline, Embase, PubMed, ERIC) in December 2022 and screened according to the
PRISMA 2020 statement. Inclusion: School aged participants (4-18 years) with a primary internalising disorder; psychotherapy delivered in a routine
setting (e.g. outpatient clinic, school) by setting staff; compared psychotherapy to any control in a randomised controlled trial; reported pre-to-
post or pre-to-follow-up comparisons on the primary disorder according to child, parent or independent evaluator report; and was published in
English. Risk of bias was assessed using the ROB 2.0 Cochrane tool. Results were synthesised using random effects to pool estimates. Risk ratios were
used to analyse dichotomous data and standardised mean differences (SMD) for continuous data. Forty-five studies were included (N = 4901
participants; M = 13 years; range 8-16; SD = 2.5). Nine used waitlist control, 17 treatment as usual, 4 placebo; 15 compared psychotherapy to active
control. Psychotherapy was associated with small significant effects pre- to post-treatment compared to non-active controls for anxiety (SMD = - 0.24
to 0.50) and depression (SMD = - 0.19 to 0.34) with effects differing by informant. Psychotherapy led to small significant pre-to-post-benefits in
youth internalising disorders in routine settings. Results are limited by reporter type and follow-up.
Clinical Child &
Family Psychology Review, 14 : 14
- Year: 2023
- Problem: Anxiety Disorders (any), Obsessive Compulsive Disorder, Post Traumatic Stress Disorder, Depressive Disorders
- Type: Systematic reviews
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any)
Wright, M., Reitegger, F., Cela, H., Papst, A., Gasteiger-Klicpera, B.
The
availability of digital tools aiming to promote adolescent mental health is rapidly increasing. However, the field lacks an up-to-date and focused
review of current evidence. This study thus looked into the characteristics and efficacy of digital, evidence-based mental health programs for youth
(11-18 years). The selection procedure followed the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines and
resulted in 27 eligible studies. The high heterogeneity of the results calls for careful interpretation. Nevertheless, small, but promising, effects
of digital tools were found with respect to promoting well-being, relieving anxiety, and enhancing protective factors. Some important factors
influencing overall efficacy include the given setting, the level of guidance and support, and the adherence to the intervention.
Journal of Youth & Adolescence, 52(4) : 754-779
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Technology, interventions delivered using technology (e.g. online, SMS)
Wisman, M. A., Emmelkamp, J., Dekker, J. J. M., Christ,
C.
Background: Dysfunctional
emotion regulation (ER) is associated with symptoms of depression and anxiety in adolescents. This pilot study aimed to examine the acceptability and
feasibility of a guided internet-based emotion regulation training (ERT) added to cognitive behavioral therapy (CBT). Furthermore, we aimed to
examine the feasibility of the randomized study design and to provide a first estimate of the effectiveness of CBT + ERT compared with CBT alone in
adolescents with depressive or anxiety disorders. Method(s): In a pilot randomized controlled trial (RCT) with a parallel group design, 39 patients
(13-18 years) with depressive or anxiety disorder were assigned to CBT + ERT (n = 21) or CBT (n = 18). Assessments at baseline, three-months and
six-months follow-up included treatment adherence, satisfaction, depressive symptoms, anxiety symptoms, and ER strategies. Result(s): Adherence to
ERT was 66.5 %, and treatment satisfaction was adequate. 76.5 % of eligible patients participated in the study. Linear mixed-model analyses showed
significantly reduced anxiety symptoms (p = .003), depressive symptoms (p = .017), and maladaptive ER (p = .014), and enhanced adaptive ER (p = .008)
at six months follow-up in the CBT + ERT group compared to controls. Limitation(s): The sample size was small, and results regarding effectiveness
remain preliminary. Data-collection took place during COVID-19, which may have influenced the results. Conclusion(s): Both the intervention and the
study design were found to be feasible. In a larger RCT, however, improvement of recruitment strategy is necessary. Preliminary results indicate
potential effectiveness in decreasing anxiety, depression, and emotion dysregulation in adolescents. The next step should be the development of an
improved internet-based ERT and its evaluation in a larger RCT. Trial registration: Registered on January 14th, 2020 in The Netherlands Trial
Register (NL8304). Copyright © 2022 The Authors
Internet Interventions, 31 (no pagination) :
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Other Psychological Interventions, Technology, interventions delivered using technology (e.g. online, SMS)
Wirehag-Nordh, E-L., Grip,
K., Thorvaldsson, V., Priebe, G., Afzelius, M., Axberg, U.
Aim: To investigate the effectiveness of
preventive interventions for 8 - 17-year-old\rchildren of patients diagnosed with depression, anxiety, or bipolar disorder.\rMethods: Sixty-two
families including 89 children received either the more extensive\rFamily Talk Intervention (FTI; n = 35), the brief Let's Talk about Children (LTC;
n = 16),\ror Interventions as Usual (IAU; n = 38) in routine care in adult psychiatry. Parentrated questionnaire data were collected at baseline,
after 6 and 12 months. We used\rgrowth curve models to investigate the effect of intervention on child mental health\rproblems (SDQ-P Total
Difficulties) and perceived parental control of child behaviour\r(PLOC-PPC).\rResults: Parents in the FTI and LTC groups, versus the IAU group,
reported more favourable development in terms of preventing increase in child mental health problems\rwith standardised intervention effects of d =
Acta Paediatrica, 112(1) : 132-
142
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Controlled clinical trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Winkler, A., Hahn,
A., Hermann, C.
Open-label placebo
(OLP) may be utilized to reduce psychological distress. Yet, potential contextual effects have not been explored. We investigated the impact of
pharmaceutical form and the simulation of side effects in a parallel group RCT (DRKS00030987). A sample of 177 highly stressed university students at
risk of depression were randomly assigned by computer generated tables to a 1-week intervention with active or passive OLP nasal spray or passive OLP
capsule or a no-treatment control group. After the intervention, groups differed significantly in depressive symptoms but not regarding other
outcomes of psychological distress (stress, anxiety, sleep quality, somatization), well-being or treatment expectation. OLP groups benefitted
significantly more compared to the no-treatment control group (d=.40), OLP nasal spray groups significantly more than the OLP capsule group (d=.40)
and the active OLP group significantly more than the passive OLP groups (d=.42). Interestingly, before intervention, most participants, regardless of
group assignment, believed that the OLP capsule would be most beneficial. The effectiveness of OLP treatments seems to be highly influenced by the
symptom focus conveyed by the OLP rationale. Moreover, pharmaceutical form and simulation of side effects may modulate efficacy, while explicit
treatment expectation seems to play a minor role. Copyright © 2023. The Author(s).
Scientific reports, 13(1) : 6367
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Weintraub, M. J., Denenny, D., Ichinose, M. C., Zinberg, J., Morgan-Fleming, G., Done, M., Brown, R. D., Bearden, C. E., Miklowitz, D. J.
OBJECTIVES: There is substantial evidence that cognitive behavioral therapy (CBT) and mindfulness-based cognitive therapy (MBCT)
improve symptoms and functioning in adults with mood and psychotic disorders. There has been little work directly comparing these treatments among
adolescents with early-onset mood or psychosis symptoms.\rMETHOD: We conducted a randomized controlled trial comparing remotely administered group
CBT to group MBCT for adolescents (ages 13-17) with a mood disorder or attenuated psychosis symptoms. Adolescents attended nine sessions over 2
months; their parents attended parallel groups focused on the same skill practices. Participants were assessed for psychiatric symptoms and
functioning at posttreatment and 3 months posttreatment.\rRESULTS: Sixty-six youth (Mage = 15.1 years, SD = 1.4; 44 females [66.7%])
initiated the trial (32 in CBT and 34 in MBCT), with 54 retained at posttreatment and 53 at the 3-month follow-up. The treatments were associated
with comparable improvements in adolescents' mood, anxiety, attenuated psychosis symptoms, and psychosocial functioning over 5 months. CBT was
associated with greater improvements than MBCT in emotion regulation and well-being during the posttreatment period. MBCT (compared to CBT) was
associated with greater improvements in social functioning among adolescents with greater childhood adversity. Both treatments had comparable rates
of retention, but youth and parents reported more satisfaction with CBT than MBCT.\rCONCLUSIONS: The beneficial effect of both treatments in a group
telehealth format is encouraging. Due to our limited sample, future research should investigate whether adolescents' history of adversity and
treatment preferences replicate as treatment moderators for youth with mood or psychosis symptoms. (PsycInfo Database Record (c) 2023 APA, all rights
reserved).
Journal
of Consulting & Clinical Psychology, 91(4) : 234-241
- Year: 2023
- Problem: Anxiety Disorders (any), Bipolar Disorders, Depressive Disorders, Psychosis Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Mindfulness based
therapy, Technology, interventions delivered using technology (e.g. online, SMS)
Wei, M. X., Liu, Z.
Background: The aim of this study was to explore the mechanisms underlying the association between
exercise intervention and mental health, and our questionnaire-based study aimed to compare the psychological effects of 6\rweeks of exercise among
123 Chinese university students.\rMaterial/Methods: A total of 123 college students were randomly divided into the experimental group (80 patients)
and the control group (43 patients). The experimental group participated in a 6-week exercise intervention, and the control group received no
intervention. Questionnaires were used to study emotion regulation and mental health.\rResults: The exercise intervention has a significant effect on
reducing the anxiety and depression levels of college students [F(1,122)=10.83, p<0.01, F(1,122)=9.63, p<0.01]. Male students were superior to female
students in perceived self-efficacy in managing despondency/distress [F(1,122)=26.77, p<0.01] and emotion suppression\r[F(1,122)=6.13, p<0.05]. The
anxiety factors of female students [F(1,122)=10.06, p<0.05] and depression factors [F(1,122)=9.86, p<0.01] were significantly higher than in male
students.\rConclusions: Our study shows that a 6-week exercise intervention significantly improved the mental health of college students. Aiming to
determine the mechanism underlying the influence of exercise intervention on college students' mental health, this paper proposes a new structural
relationship. Emotion regulation self-efficacy and\remotion regulation strategy play a mediating role in the relationship between physical education
and mental\rhealth. Physical education teachers in colleges and universities should actively carry out physical education,\rmake full use of the
distinctive characteristics and advantages of physical education, and purposefully and systematically guide college students to actively participate
in physical exercise.
Medical Science Monitor
Basic Research, 29 : e939096
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Physical activity, exercise
Waraan, L., Siqveland, J., Hanssen-Bauer, K., Czjakowski, N. O., Axelsdottir, B., Mehlum, L., Aalberg, M.
OBJECTIVE: To systematically review and meta-analyze the
effectiveness of family therapy compared to other active treatments for adolescents with depressive disorders or suicidal ideation.\rMETHOD: We
conducted a systematic search of The Cochrane Central Register of Controlled Trials, Medline, Embase, PsycINFO, AMED, CINAHL and Web of Science and
performed two meta-analyses of outcomes for depressive symptoms and suicidal ideation.\rRESULTS: We screened 5,940 records and identified 10
randomized controlled studies of family therapy for depressive disorder or suicidal ideation in adolescents with an active treatment comparison
group. Nine studies reported outcome measures of depressive symptoms and four reported outcome measures of suicidal ideation. The meta-analysis
showed no significant difference between family therapy and active comparison treatments for end-of-treatment levels of depression. For suicidal
ideation our meta-analysis showed a significant effect in favour of family therapy over comparison treatments for suicidal ideation.\rCONCLUSIONS:
Based on the current body of research, we found that family therapy is not superior to other psychotherapies in the treatment of depressive disorder.
However, family therapy leads to significantly improved outcomes for suicidal ideation, compared to other psychotherapies. The evidence for the
treatment of depression is of low quality needs more research.
, 28(2) : 831-849
- Year: 2023
- Problem: Depressive Disorders, Suicide or self-harm behaviours (excluding non-suicidal self-harm)
- Type: Systematic reviews
-
Stage: Disorder established (diagnosed disorder), At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Family therapy
Wang, Y., Jia, N., Zhou,
Y., Fu, L., Fan, L., Li, B.
Aim: To compare the differences in the effects of
based on remote coached high intensity interval training and combined exercise training on the physical and mental health of university students.
\rMethod: Sixty university students were recruited from Shandong Normal University and randomly divided into HIIT group (n = 30) and AR group (n =
30), with the HIIT group using high-intensity interval training intervention and the AR group using combined exercise (aerobic combined with
resistance) training intervention for 8 weeks. Mental health indicators, fitness indicators and body composition indicators were measured at the
beginning and end of the intervention.\rResults: After 8 weeks, among the mental health indicators, the results of the Symptom Self-Rating Scale
(SCL-90) test showed a significant improvement in the HIIT group in terms of total score, somatization, obsessive-compulsive, interpersonal
sensitivity, depression, hostility, and psychoticism (p < 0.05); the AR group showed significant improvements in psychoticism (P < 0.05). There were
no significant differences between the two groups. The results of the Pittsburgh Sleep Quality Index scale (PSQI) showed a significant difference in
sleep efficiency in the HIIT group with an inverse improvement in scores; the AR group showed no significant improvement in each test item. The
results of the between-group covariance showed significant differences in sleep efficiency and hypnotic drugs in the HIIT group (p < 0.05). Among the
fitness indicators, the HIIT group showed significant improvements in maximum oxygen uptake, grip strength and flexibility (P < 0.05); the AR group
showed significant improvements in back muscle strength and flexibility (P < 0.05). The results of the between-group covariance showed significant
improvements in maximum oxygen uptake in the HIIT group (P < 0.01). Regarding body composition indicators, there was a significant improvement in
Body weight, BMI, Body fat percentage and Waist-to-hip ratio in both the HIIT and AR groups (P < 0.01). There were no significant differences between
the two groups.\rConclusion: HIIT and combined exercise training based on remote coaching had some improvement on fitness level and body composition
of university students, HIIT was more advantageous in improving aerobic endurance, and HIIT based on remote coaching may have better effect than
combined exercise in mental health.\rTrial registration: Chinese Clinical Trial Register, ChiECRCT20220149. Registered on 16 May 2022.
, 14 : 1182332
- Year: 2023
- Problem: Anxiety Disorders (any), Obsessive Compulsive Disorder, Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Service Delivery & Improvement, Physical activity, exercise, Technology, interventions delivered using technology (e.g. online, SMS)
Wang,
R., Cai, Y., Lu, W., Zhang, R., Shao, R., Yau, S. Y., Stubbs, B., McIntyre, R. S., Su, K. P., Xu, G., Qi, L., So, K. F., Lin, K.
This 3-month randomized psychoeducation-controlled
trial (RCT) of exercise was undertaken in young adolescents with subthreshold depression to examine the impact on gut microbiota. Participants (aged
12-14 years) were randomly assigned to an exercise or a psychoeducation-controlled group. The exercise intervention arm took moderate-intensity
exercise, comprised of 30 min of running per day, 4 days a week for 3 months. Psychoeducation intervention consisted of 6 sessions of group activity
including gaming, reading, and singing. The gut microbiota was assessed by metagenomic sequencing. After 3-month moderate-intensity exercise, the
intervention group increased the relative abundance of Coprococcus, Blautia, Dorea, Tyzzerella at the genus level, as well as Tyzzerella nexilis,
Ruminococcus obeum at species level when compared to the psychoeducation-controlled group. Moreover, EggNOG analyses showed that the defense and
signal transduction mechanism were highly enriched after the active intervention, and changes were correlated with improvements in depressive
symptoms measured by Chinese Patient Depression Questionnaire 9. The KEGG pathway of neurodegenerative diseases was depleted in the microbiome in
young adolescents with subthreshold depression after exercise intervention. This 3-month RCT suggests that at both the genus and species levels,
aerobic group exercise intervention improved in depressive symptoms and revealed changes in gut microbiota suggesting beneficial effects.
Psychiatry Research, 319 : 115005
- Year: 2023
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Psychological Interventions
(any), Psychoeducation, Physical activity, exercise
Wang, Q., An, S., Shao, Z.
The COVID-19 pandemic has been suggested to cause psychological problems such as anxiety, depression,
panic, and insomnia. This systematic review and meta-analysis aims to assess the efficacy of psychological interventions (including CBT, DBT, and
mindfulness based interventions) in reducing distressing feelings in college students during the COVID- 19 pandemic. Randomized controlled trials
(RCTs) on psychological interventions for reducing negative emotions among college students during the COVID-19 epidemic were searched in databases
Web of Science, PubMed, Cochrane Library, Embase, Scopus, PsychInfo, CNKI, WanFang, and VIP. We utilized Cochrane risk of bias assessment technique
to assess the quality of included RCTs. The data were analyzed using RevMan 5.4. Eight RCTs were finally included involving 1,496 participants.
According to the meta-analysis results, psychotherapies could significantly alleviate anxiety, depression, and stress symptoms among university
students, [MD = -0.98, 95%CI (-1.53, -0.43), p<0.001] [SMD = -0.47, 95%CI (-0.77, -0.16), p = 0.003] [MD = -1.53, 95%CI (-2.23, -0.83), p <0.001].
The difference in attenuation of somatization symptoms between the two groups was not statistically significant [SMD = -0.42, 95%CI (-1.41, 0.56), p
= 0.40]. Psychotherapy might effectively alleviate anxiety, depression, and stress in university students caused by the COVID-19 pandemic. It could
be considered the preferred strategy for reducing negative emotions and improving the quality of life of university students. Copyright © 2023 Wang
et al.
PLoS ONE, 18(5 May) (no pagination) :
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Dialectical behavioural therapy
(DBT), Mindfulness based
therapy