Disorders - depressive disorders
Tokolahi, E., Vandal, A. C., Kersten,
P., Pearson, J., Hocking, C.
Background: The impact of
occupational therapy on mental health outcomes for children is largely unexplored. The aim of this study was to investigate an evidence-based
occupational therapy intervention designed to increase participation in daily occupations to prevent symptoms of mental illness for children and run
in schools. Method(s): The study used a pragmatic, cluster-randomised controlled trial design with two arms. Fourteen clusters (schools), equating to
151 child participants, were stratified by school decile-rank category and block randomised. Blinding of participants post-randomisation was not
feasible; however, outcomes assessors were blinded. Outcomes were measured at baseline, after the parallel and crossover phases, and at follow-up;
and were anxiety symptoms (primary), depression symptoms, self-esteem, participation and wellbeing. Intention-to-treat analysis was applied and mixed
linear modelling was used to account for clusters and repeated measures, and to adjust for covariates identified. Result(s): This trial found
significant positive effects of the intervention on child-rated satisfaction with their occupational performance and teacher-rated child anxiety. No
evidence was found to support the effect of the intervention on anxiety and depression symptoms, self-esteem and wellbeing. Conclusion(s): This was
the first known cluster-randomised controlled trial to investigate an occupational therapy intervention promoting emotional wellbeing in a non-
clinical sample of children. No compelling evidence was found to support the use of the intervention in schools in its current format, however,
results were promising that the focus on occupations influenced participation. Recommendations are made to redesign the intervention as an embedded
intervention in the classroom, cotaught by teachers and including parental involvement. Copyright © 2018 Association for Child and Adolescent Mental
Health
Child and Adolescent
Mental Health, 23(4) : 313-327
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Other Psychological Interventions, Other service delivery and improvement
interventions
Amirzadegan, M., Ghahari, S., Asgharnejad Farid, A. A.
Aims and context.- Child sexual
abuse is one of the most common psycho-social health problem which bring so many negative consequences for the child. The current study is aimed on
comparison the efficiency of play and narrative therapy on decreasing depression, anxiety and aggression of sexually abused children. Methodology.-
The current study is an experimental research along pre-test, post-test and a control group. The statistical group was included all the children
between 7 to 12 years old who visited Rooyesh Nahal Tehran Institute in 2017. Among this group, 45 victim children (sexually abused) were selected by
means of available sampling method and divided into the two experimental groups: 1- play therapy 2-narrative therapy, and one control group randomly
(Each group was included 15 people). Experimental groups was intervened by play and narrative therapy separately during 10 sessions, and control
group was put on the waiting list. Both groups filled these questionnaires at the baseline and after treatment: Children and Adolescent Depression
Scale (C.A.D.S), Multidimensional anxiety scale for children (M.A.S.C). The data analyzed through the descriptive and deductive statistical analysis
(covariance analysis. ANCOVA). Findings.- The results of multivariable covariance analysis were referred to a significant differences between two
experimental groups with the control group. The Comparison of experimental groups pointed that the narrative therapy in compare with play therapy had
more efficiency on decreasing the level of anxiety and aggression among sexually abused children (P < 0.05) while the play therapy was more effective
than narrative therapy in reducing depression of sexually abused children (P < 0.05). Conclusion.- Narrative therapy has more efficiency than the
play therapy on decreasing level of anxiety and aggression of sexually abused children, and play therapy is more effective than narrative therapy on
reducing depression of sexually abused children.
European Psychiatry, 48 (Supplement
1) : S143
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Controlled clinical trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions, Narrative exposure therapy (NET)
Kreuze, L. J., Pijnenborg, G. H. M., de-Jonge, Y. B., Nauta, M. H.
Anxiety-focused cognitive-behavioral therapy (CBT) effectively reduces anxiety in children and adolescents. An
important remaining question is to what extent anxiety-focused CBT also affects broader outcome domains. Additionally, it remains unclear whether
parental involvement in treatment may have impact on domains other than anxiety. A meta-analysis (nstudies = 42, nparticipants
= 3239) of the effects of CBT and the moderating role of parental involvement was conducted on the following major secondary outcomes: depressive
symptoms, externalizing behaviors, general functioning, and social competence. Randomized controlled trials were included when having a waitlist or
active control condition, a youth sample (aged<19) with a primary anxiety disorder diagnosis receiving anxiety-focused CBT and reported secondary
outcomes. Controlled effect sizes (Cohen's d) were calculated employing random effect models. CBT had a large effect on general functioning (-1.25
[-1.59;0.90], nstudies = 17), a small to moderate effect on depressive symptoms (-0.31[-0.41;-0.22], nstudies = 31) and a small
effect on externalizing behaviors (-0.23[-0.38;-0.09], nstudies = 12) from pre-to post-treatment. Effects remained or even further
improved at follow-up. Social competence only improved at follow-up (nstudies = 6). Concluding, anxiety-focused CBT has a positive effect
on broader outcome domains than just anxiety. Higher parental involvement seemed to have beneficial effects at follow-up, with improvements in
general functioning and comorbid symptoms. Copyright © 2018 Elsevier Ltd
Journal of Anxiety Disorders, 60 : 43-57
- Year: 2018
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT)
Bentley, K.
H., Boettcher, H., Bullis, J. R., Carl, J. R., Conklin, L. R., Sauer-Zavala, S., Pierre-
Louis, C., Farchione, T. J., Barlow, D. H.
Cognitive-behavioral prevention programs have demonstrated efficacy in reducing subclinical symptoms of anxiety and depression, and there
is some evidence to suggest that they can lower the risk of future disorder onset. However, existing interventions tend to be relatively lengthy and
target specific disorders or problem areas, both of which limit their potential for widespread dissemination. To address these limitations, we aimed
to develop a single-session, transdiagnostic preventive intervention based on the Unified Protocol for Transdiagnostic Treatment of Emotional
Disorders for young adults at risk for developing anxiety and/or depressive disorders within a college setting. Results from this proof-of-concept
study indicated that the intervention was viewed as highly satisfactory and acceptable. The intervention also was successful at delivering adaptive
emotion management skills in its 2-hr workshop format. Future studies evaluating the efficacy of this novel transdiagnostic, emotion-focused
prevention program are warranted.
Behavior Modification, 42(5) : 781-805
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Barrera, M., Atenafu, E., Nathan, P.C., Schulte, F., Hancock, K.
Objective: The objective of this study was to (1) assess the effects of a group intervention
called Siblings Coping Together on siblings' psychosocial adjustment compared with controls; (2) explore the potential moderating effect of
siblings' gender; and (3) investigate whether the intervention was more effective for siblings with more depressive symptoms at baseline. Methods:
This was a repeated measure, parallel randomized controlled trial (RCT) with two groups. Seventy-five healthy siblings (7-16 years old, 41 males)
participated. Both groups had 8 weekly 2-hr sessions. Intervention sessions had psychoeducational, social, and therapeutic problem-solving goals
taught through games and crafts (n = 41); controls (n = 34) had games and crafts only. Self-reported symptoms of depression (Children's Depression
Inventory, CDI) and self- and proxy-reported quality of life (QOL) (Pediatric Quality of Life Inventory, PedsQL) were obtained at baseline,
postintervention, and 3 months later. Multivariable analyses with a mixed effects model were performed. Results: No significant main group effect or
group x time interactions were found for any of the scales assessed. Significant improvement over time was found for total CDI (p < .01) and proxy-
reported PedsQL total (p < .001) in both groups, which may have been attributable to the passage of time. Conclusions: No sufficient evidence was
obtained for the efficacy of the intervention in the current study. Future research may examine conducting a larger RCT comparing sibling support
group to no treatment control group. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
Journal of Pediatric Psychology, 43(10) : 1093-1103
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Gabbay, V., Freed, R. D., Alonso, C. M., Senger, S., Stadterman, J., Davison, B. A., Klein, R. G.
Objective: Reports are mixed on the efficacy of omega-3 fatty acids (O3FA) for the treatment of major depressive disorder (MDD), with
only limited data in adolescents. The present trial aimed to investigate systematically the efficacy of O3FA as a monotherapy, compared to a placebo,
in adolescents with MDD. Secondarily, we explored O3FA effects on anhedonia, irritability, and suicidality-all key features of adolescent MDD.
Method(s): Fifty-one psychotropic medication-free adolescents with DSM-IV-TR diagnoses of MDD (aged 12-19 years; 57% female) were randomized to
receive O3FA or a placebo for 10 weeks. Data were collected between January 2006 and June 2013. O3FA and a placebo were administered on a fixed-
flexible dose titration schedule based on clinical response and side effects. The initial dose of 1.2 g/d was increased 0.6 g/d every 2 weeks, up to
a maximum of 3.6 g/d. Clinician-rated and self-rated depression severity, along with treatment response, served as primary outcome measures.
Additionally, we examined O3FA effects on depression-related symptoms, including anhedonia, irritability, and suicidality. Treatment differences were
analyzed via intent-to-treat analyses. Result(s): O3FA were not superior to a placebo on any clinical feature, including depression severity and
levels of anhedonia, irritability, or suicidality. Additionally, response rates were comparable between treatment groups. Within-treatment analyses
indicated that both treatments were associated with significant improvement in depression severity on self- (O3FA: t= -4.38, P< .001; placebo: t= -
3.52, P= .002) and clinician (O3FA: t= -6.47, P< .001; placebo: t= -8.10, P< .001) ratings. Conclusion(s): In adolescents with MDD, O3FA do not
appear to be superior to placebo. © Copyright 2018 Physicians Postgraduate Press, Inc.
Journal of Clinical Psychiatry, 79 (4) (no
pagination)(17m11596) :
- Year: 2018
- Problem: Depressive Disorders, Suicide or self-harm behaviours (excluding non-suicidal self-harm), Suicide or self-harm with comorbid mental disorder
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder), At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Fish oil (Omega-3 fatty acids), Omega 3 fatty
acids (e.g. fish oil, flax oil)
Yamamoto, A., Tsujimoto, E., Taketani, R., Tsujii, N., Shirakawa, O., Ono, H.
Background: Subthreshold depression and poor stress coping strategies are major
public health problems among undergraduates. Interpersonal counseling (IPC) is a brief structured psychological intervention originally designed for
use in primary care to treat depressive patients whose symptoms arose from current life stress. Objectives: This study examined the efficacy of IPC
in treating subthreshold depression and coping strategies among undergraduates in school counseling. Materials and Methods: We carried out an
exploratory randomized controlled trial comparing the efficacy of IPC with counseling as usual (CAU). Participants were 31 undergraduates exhibiting
depression without a psychiatric diagnosis. Results: The Zung Self-Rating Depression Scale total score decreased significantly in the IPC group (n =
15; Z = -2.675, p = .007), but not in the CAU group (n = 16). The task-oriented coping score of the Coping Inventory for Stressful Situations showed
a tendency towards a greater increase in the IPC group than in the CAU group (t = 1.919, df = 29, p = .065). Conclusions: The IPC might be more
useful for student counseling because it can teach realistic coping methods and reduce depressive symptoms in a short period. Further studies using
more participants are required. (PsycINFO Database Record (c) 2018 APA, all rights reserved)
Depression Research and
Treatment, 2018(ArtID 4201897) :
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Interpersonal therapy (IPT), Supportive
therapy
Gladstone, T., Terrizzi, D., Stinson, A., Nidetz, J., Canel, J., Ching, E., Berry, A., Cantorna, J., Fogel, J., Eder, M., Bolotin, M., Thomann, L. O., Griffith,
K., Ip, P., Aaby, D. A., Brown, C. H., Beardslee, W., Bell, C., Crawford, T. J., Fitzgibbon, M., Schiffer, L., Liu, N., Marko-Holguin, M., Van-Voorhees, B. W.
Importance: Although 13-20% of American adolescents
experience a depressive episode annually, no scalable primary care model for adolescent depression prevention is currently available. Objective(s):
To study whether CATCH-IT (Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training) reduces the hazard for
depression in at-risk adolescents identified in primary care, as compared to a general health education attention control (HE). Design(s): The
Promoting AdolescenT Health (PATH) study compares CATCH-IT and HE in a phase 3 single-blind multicenter randomized attention control trial.
Participants were enrolled from 2012 to 2016 and assessed at 2, 6, 12, 18, and 24 months post-randomization. Setting(s): Primary care. Participant
(s): Eligible adolescents were 13-18 years with subsyndromal depression and/or history of depression and no current depression diagnosis or
treatment. Of 2,250 adolescents screened for eligibility, 446 participants completed the baseline interview and 369 were randomized into CATCH-IT
(n=193) and HE (n=176). Intervention(s): CATCH-IT is a 20-module (15 adolescent modules, 5 parent modules) online psychoeducation course that
includes a parent program, supported by three motivational interviews. Main Outcomes and Measures: Time-to-event for depressive episode; depressive
symptoms at 6 months. Result(s): Mean age was 15.4 years, and 68% were female; 28% had both a past episode and subsyndromal depression; 12% had a
past episode only, 59% had subsyndromal depression only, and 1% had borderline subsyndromal depression. The outcome of time-to-event favored CATCH-IT
but was not significant with intention-to-treat analyses (N=369; unadjusted HR=0.59; 95% CI 0.27, 1.29; p=0.18; adjusted HR=0.53; 95% CI 0.23, 1.23,
p=0.14). Adolescents with higher baseline CES-D10 scores showed a significantly stronger effect of CATCH-IT on time-to-event relative to those with
lower baseline scores (p=0.04). For example, for a CES-D10 score of 15 (significant sub-syndromal depression), HR=0.20 (95% CI 0.05, 0.77), compared
to CES-D10 of 5 (no sub-syndromal depression), HR=1.44 (95% CI, 0.41, 5.03). In both CATCH-IT and HE groups, depression symptoms declined and
functional scores increased. Conclusions and Relevance: CATCH-IT may be better than HE for preventing depressive episodes for at-risk adolescents
with sub-syndromal depression. CATCH-IT may be a scalable approach to prevent depressive episodes in adolescents in primary care.
JAMA network open, 1(7) :
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Interpersonal therapy (IPT), Motivational interviewing, includes Motivational Enhancing Therapy, Psychoeducation, Other Psychological Interventions, Technology, interventions delivered using technology (e.g. online, SMS)
Noh, D.
The effects of a resilience enhancement programme on resilience,
depression, anxiety, and problem drinking among female runaway youths living in shelters were evaluated. Participants were 32 youths (16 experimental
and 16 control participants), assessed at pre-test, post-test, and one-month follow-up. The programme incorporated five protective factors associated
with resilience: self-esteem, self-regulation, relational skills, problem-solving skills, and goal-setting skills. There were significant group-by-
time interaction effects for resilience, anxiety, and problem drinking at one-month follow-up. The preliminary results suggest that providing female
runaway youths with this programme focusing on protective factors may enhance resilience and mitigate anxiety, and problem drinking.
Issues in Mental Health
Nursing, 39(9) : 764-772
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders, Alcohol
Use
- Type: Controlled clinical trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Harrer, M., Adam, S. H., Fleischmann, R. J., Baumeister, H., Auerbach, R., Bruffaerts, R., Cuijpers,
P., Kessler, R. C., Berking, M., Lehr, D., Ebert, D. D.
BACKGROUND: Mental health problems are highly prevalent among college students. Most students
with poor mental health, however, do not receive professional help. Internet-based self-help formats may increase the utilization of treatment.
OBJECTIVE(S): The aim of this randomized controlled trial was to evaluate the efficacy of an internet-based, app-supported stress management
intervention for college students. METHOD(S): College students (n=150) with elevated levels of stress (Perceived Stress Scale 4-item version, PSS-4
>=8) were randomly assigned to either an internet- and mobile-based stress intervention group with feedback on demand or a waitlist control group.
Self-report data were assessed at baseline, posttreatment (7 weeks), and 3-month follow-up. The primary outcome was perceived stress posttreatment
(PSS-4). Secondary outcomes included mental health outcomes, modifiable risk and protective factors, and college-related outcomes. Subgroup analyses
were conducted in students with clinically relevant symptoms of depression (Center for Epidemiological Studies' Depression Scale >17). RESULT(S): A
total of 106 participants (76.8%) indicated that they were first-time help-seekers, and 77.3% (intervention group: 58/75; waitlist control group:
58/75) showed clinically relevant depressive symptoms at baseline. Findings indicated significant effects of the intervention compared with the
waitlist control group for stress (d=0.69; 95% CI 0.36-1.02), anxiety (d=0.76; 95% CI 0.43-1.09), depression (d=0.63; 95% CI 0.30-0.96), college-
related productivity (d=0.33; 95% CI 0.01-0.65), academic work impairment (d=0.34; 95% CI 0.01-0.66), and other outcomes after 7 weeks
(posttreatment). Response rates for stress symptoms were significantly higher for the intervention group (69%, 52/75) compared with the waitlist
control group (35%, 26/75, P<.001; number needed to treat=2.89, 95% CI 2.01-5.08) at posttest (7 weeks). Effects were sustained at 3-month follow-up,
and similar findings emerged in students with symptoms of depression. CONCLUSION(S): Internet- and mobile-based interventions could be an effective
and cost-effective approach to reduce consequences of college-related stress and might potentially attract students with clinically relevant
depression who would not otherwise seek help. TRIAL REGISTRATION: German Clinical Trial Register DRKS00010212;
http://www.drks.de/drks_web/navigate.do? navigationId=trial.HTML&TRIAL_ID=DRKS00010212 (Archived by WebCite at http://www.webcitation.org/6w55Ewhjd).
Copyright ©Mathias Harrer, Sophia Helen Adam, Rebecca Jessica Fleischmann, Harald Baumeister, Randy Auerbach, Ronny Bruffaerts, Pim Cuijpers, Ronald
C Kessler, Matthias Berking, Dirk Lehr, David Daniel Ebert. Originally published in the Journal of Medical Internet Research (http://www.jmir.org),
23.04.2018.
Journal of Medical Internet
Research, 20(4) : e136
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Problem solving therapy (PST), Other Psychological Interventions, Technology, interventions delivered using technology (e.g. online, SMS)
Choukri, M. A., Conner,
T. S., Haszard, J. J., Harper, M. J., Houghton, L. A.
Epidemiological evidence has linked low
vitamin D status to a range of mood disorders. However, studies examining whether vitamin D supplementation can improve mood-related outcomes in
healthy populations are limited. We investigated whether vitamin D supplementation over winter is beneficial for improving mood-related outcomes in
healthy women. A total of 152 healthy women (18-40 years) in Dunedin, New Zealand were randomly assigned to receive 50 000 IU (1.25 mg) of oral
vitamin D3 or placebo once per month for 6 months. They completed the Center for Epidemiologic Studies Depression Scale, the anxiety
subscale of the Hospital Anxiety and Depression Scale and the Flourishing Scale every month. Additionally, they reported their positive and negative
mood each day for three consecutive days every 2 months. Participants provided a blood sample at the beginning and at the end of the study for 25-
hydroxyvitamin D3 analysis. ANCOVA was used to compare the outcome measures between the groups, controlling for baseline. We found no
evidence of lower depression (P = 0.339), lower anxiety (P = 0.862), higher flourishing (P = 0.453), higher positive moods (P = 0.518) or lower
negative moods (P = 0.538) in the treatment group compared with the control group at follow-up. Mood outcomes over the study period were similar for
the two groups. We found no evidence of any beneficial effect of monthly vitamin D3 supplementation on mood-related outcomes in healthy
premenopausal women over the winter period, so recommendations for supplementations are not warranted in this population for mood-related outcomes.
Copyright © The Author(s) 2018.
Journal of Nutritional
Science., :
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Vitamins and supplements
Takagaki, K., Jinnin, R., Mori, A., Nishiyama, Y., Yamamura, T., Yokoyama, S., Shiota, S., Okamoto, Y., Miyake, Y., Ogata, A., Kunisato, Y., Shimoda, H., Kawakami,
N., Furukawa, T. A., Yamawaki, S.
Background: No significant effect of psychological treatment has been reported from meta-
analysis of subthreshold depression patients and control subjects at 1-year follow-up. However, behavioral activation is a simpler and more cost-
effective treatment than cognitive behavioral therapy. The primary purpose of this study was to assess by comparison to an assessment-only control
group whether the effects of behavioral activation program for depressive symptoms can persist up to 1-year follow-up without the use of
antidepressants or other psychotherapy. Patients and Methods: Late adolescent students were the population targeted in this study. Participants were
allocated randomly to an intervention group (n=62) or a control group (n=56). Treatment consisted of five-weekly 60-minute sessions. Participants
underwent a structured interview and completed self-report scales at 1 year post-assessment. Result(s): Late adolescent students receiving treatment
had significantly lower mean Beck Depression Inventory, second edition scores at 1-year follow-up than control group students. The effect size
(Hedges' g) for between-group differences at 1-year follow-up was-0.41. Conclusion(s): Our behavioral activation program is simple and short.
Nevertheless, the results obtained at 1-year follow-up of the control group and late adolescent students receiving treatment indicated a significant
difference in their Beck Depression Inventory, second edition scores. Our 5-week behavioral activation program based on behavioral characteristics
for subthreshold depression might be promising for subthreshold depression. The sample examined for this study imposed some study limitations.
Copyright © 2018 Takagaki et al.
Neuropsychiatric Disease and
Treatment, 14 : 2633-2641
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT)