Disorders - depressive disorders
Glass, N. E., Clough, A., Messing, J. T., Bloom, T., Brown, M. L., Eden, K. B., Campbell, J. C., Gielen, A., Laughon, K., Grace, K. T., Turner, R. M., Alvarez, C., Case, J., Barnes-Hoyt, J., Alhusen, J., Hanson, G. C., Perrin, N. A.
The objective of this study was to examine differences in
change over time in health and safety outcomes among female college students randomized to myPlan, a tailored safety planning app, or usual web-based
safety planning resources. Three hundred forty-six women (175 intervention, 171 control) from 41 colleges/universities in Oregon and Maryland
completed surveys at baseline, 6- and 12-months from July 2015 to October 2017. Generalized estimating equations were used to test group differences
across time. Both groups improved on four measure of intimate partner violence (IPV; Composite Abuse Scale [CAS], TBI-related IPV, digital abuse,
reproductive coercion [RC]) and depression. Reduction in RC and improvement in suicide risk were significantly greater in the myPlan group relative
to controls (p = .019 and p = .46, respectively). Increases in the percent of safety behaviors tried that were helpful significantly reduced CAS
scores, indicating a reduction in IPV over time in the myPlan group compared to controls (p = .006). Findings support the feasibility and importance
of technology-based IPV safety planning for college women. myPlan achieved a number of its objectives related to safety planning and decision-making,
the use of helpful safety behaviors, mental health, and reductions in some forms of IPV.
Journal of interpersonal violence, 37(13-
14) : NP11436-NP11459
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders, Suicide or self-harm behaviours (excluding non-suicidal self-harm), Substance Use Disorders (any)
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Other Psychological Interventions, Technology, interventions delivered using technology (e.g. online, SMS)
Getanda, E. M., Vostanis, P.
Background: There is limited evidence on the cultural appropriateness of first-stage psychosocial
interventions for youth with mental health problems who experience conflict and disadvantage in low- and middle-income countries (LMIC). Aim(s): To
evaluate the feasibility of such an intervention (Writing for Recovery-WfR) among youth with emerging emotional problems following internal
displacement in Kenya. Method(s): Fifty-four youth aged 14-17 years were randomly allocated to a six-session intervention or a waiting list control
group. They completed measures of stressful life events; post-traumatic stress, depressive and anxiety symptoms; quality of life; and free text on
their experience of the intervention. Result(s): Young participants reported high levels of trauma exposure and emotional problems. The intervention
was perceived as flexible and culturally acceptable, with reported short-term impact. This was found to have promising post-intervention effect in
reducing post-traumatic stress, but not depressive or anxiety symptoms; and in enhancing quality of life scores. Conclusion(s): Similar psychosocial
interventions that can be delivered by paraprofessionals are important for resource-constrained LMIC settings, but need to be integrated within a
comprehensive scaled service model. Copyright © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Journal of
Mental Health, 31(6) : 774-782
- Year: 2022
- Problem: Anxiety Disorders (any), Post Traumatic Stress Disorder, Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Psychoeducation, Other Psychological Interventions
Galloway, R., Watson, H., Greene, D., Shafran, R., Egan, S. J.
Perfectionism is a transdiagnostic process across anxiety,
depression, and eating disorders. The aim of this systematic review was to examine the efficacy of self-help and face to face CBT for perfectionism
in reducing perfectionism and anxiety, depression, and eating disorders. A total of 15 randomised controlled trials of CBT for perfectionism were
identified (N = 912 participants; mean pooled age = 23 years) which met inclusion criteria. There were medium or large effect sizes found on
perfectionism measures; personal standards (g = 0.57, 95% CI = 0.43-0.72), concern over mistakes (g = 0.89, 95% CI = 0.71-1.08) and clinical
perfectionism (g = 0.87, 95% CI = 0.70-1.04). There were medium effects for symptoms of eating disorders (g = 0.61, 95% CI = 0.36-0.87) and
depression (g = 0.60, 95% CI = 0.28-0.91), and a small-medium effect on anxiety (g = 0.42, 95% CI = 0.21-0.62). There was no publication bias found.
Limitations included the small number of trials included and lack of active treatment comparisons. Results suggested that CBT for perfectionism is
efficacious in reducing perfectionism and symptoms of depression, anxiety and eating disorders. Future research should examine comparisons of CBT for
perfectionism with other psychological treatments. (PsycInfo Database Record (c) 2022 APA, all rights reserved)
, 51(2) : 170-
184
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders, Eating Disorders
(any)
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT)
Fujino, M., Fukuda, J. Isogai, H., Ogaki, T., Mawatari, S., Takaki, A., Wakana, C., Fujino, T.
Background:
Plasmalogens have been shown to improve neurodegenerative pathology and cognitive function. We hypothesized that plasmalogens work in small amounts
as a kind of hormone interacting with a G protein-coupled receptor, and then explored the effects of scallop-derived purified plasmalogens on
psychobehavioral conditions in a randomized placebo-controlled trial of college athletes in Japan. Methods and materials: Eligible participants were
male students aged 18-22 years who belonged to university athletic clubs. They were randomly allocated to either plasmalogen (2 mg per day) or
placebo treatment of 4 weeks' duration. The primary outcome was the T-score of the Profile of Mood States (POMS) 2-Adult Short, and the secondary
outcomes included the seven individual scales of the POMS 2, other psychobehavioral measures, physical performance, and laboratory measurements. The
trial was registered at the Japan Registry of Clinical Trials (jRCTs071190028). Result(s): Forty participants (20 in the plasmalogen group and 20 in
the placebo group) completed the 4-week treatment. The Total Mood Disturbance (TMD) score of the plasmalogen group showed a greater decrease at 4
weeks than that of the placebo group while the between-group difference was marginally significant (p = 0.07). The anger-hostility and fatigue-
inertia scores of the POMS 2 decreased significantly in the plasmalogen group, but not in the placebo group, at 4 weeks. Between-group differences in
those scores were highly significant (p = 0.003 for anger-hostility and p = 0.005 for fatigue-inertia). The plasmalogen group showed a slight
decrease in the Athens Insomnia Scale at 2 weeks, and the between-group difference was near-significant (p = 0.07). The elapsed time in minute
patterns on the Uchida-Kraepelin test, which is a marker of mental concentration, revealed significantly greater performance in the plasmalogen group
than in the placebo group. There were no between-group differences in physical and laboratory measurements. Conclusion(s): It is suggested that
orally administered plasmalogens alleviate negative mood states and sleep problems, and also enhance mental concentration. Copyright © 2022 Fujino,
Fukuda, Isogai, Ogaki, Mawatari, Takaki, Wakana and Fujino.
, 10 (no pagination) :
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Fish oil (Omega-3 fatty acids), Omega 3 fatty
acids (e.g. fish oil, flax oil), Other complementary & alternative
interventions
Findling, R. L., DelBello, M.
P., Zuddas, A., Emslie, G. J., Ettrup, A., Petersen, M. L., Schmidt, S.
N., Rosen, M.
Objective: To evaluate the efficacy and safety of vortioxetine in adolescents with major depressive
disorder (MDD). Method(s): After 4 weeks of single-blind lead-in treatment with a Brief Psychosocial Intervention (BPI) plus placebo, patients (aged
12-17 years) with MDD (DSM-5) who did not meet response criteria (Children's Depression Rating Scale-Revised [CDRS-R]; total score >=40 plus <40%
reduction and a Parent Global Assessment score >2) were randomized 1:1:1:1 to 8 weeks of BPI plus double-blind treatment with vortioxetine 10 mg,
vortioxetine 20 mg, fluoxetine 20 mg, or placebo. The primary endpoint was change from randomization in CDRS-R total score at week 8; the primary
comparison was the average effect of 2 vortioxetine doses vs placebo. Result(s): Of 784 patients enrolled in the lead-in, 616 were randomized. At
week 8, the mean change in CDRS-R total score averaged for vortioxetine doses was -18.01 (SE = 0.98) and the mean difference vs placebo was 0.21 (P
=.878; not significant). For fluoxetine, the mean change in CDRS-R total score was -21.95 and the mean difference vs placebo was -3.73 (P =.015).
Treatment-emergent adverse events occurring in >=5% of patients in either vortioxetine arm and at least twice more frequently than placebo were
nausea, headache, vomiting, and dizziness. Conclusion(s): Patients in all groups showed reduction in CDRS-R scores by the end of the study, with no
difference between combined doses of vortioxetine and placebo. The primary endpoint was not met, thereby rendering the study negative. The overall
favorable safety profile of vortioxetine in an adolescent patient population was consistent with that seen in adults. Clinical trial registration
information: Active Reference (Fluoxetine) Fixed-Dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder
(MDD); http://clinicaltrials.gov; NCT02709746. Copyright © 2022 American Academy of Child and Adolescent Psychiatry
Journal of the
American Academy of Child and Adolescent Psychiatry, 61(9) : 1106-1118.e2
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Selective serotonin reuptake inhibitors (SSRIs), Antidepressants
(any)
Field, D. T., Cracknell, R. O., Eastwood,
J. R., Scarfe, P., Williams, C. M., Zheng, Y., Tavassoli, T.
Objective: Vitamins B6 and B12 are involved in metabolic
processes that decrease neural excitation and increase inhibition. This double-blind study investigated the effects of supplementation for 1 month
with a high-dose of B6 or B12, compared to placebo, on a range of behavioural outcome measures connected to the balance between neural inhibition and
excitation. Methods: 478 young adults were recruited over five linked phases. Self-reported anxiety (N = 265) and depression (N = 146) were assessed
at baseline and after supplementation. Several sensory measures acted as assays of inhibitory function and were assessed post-supplementation only;
these were surround suppression of visual contrast detection (N = 307), binocular rivalry reversal rate (N = 172), and a battery of tactile
sensitivity tests (N = 180). Results: Vitamin B6 supplementation reduced self-reported anxiety and induced a trend towards reduced depression, as
well as increased surround suppression of visual contrast detection, but did not reliably influence the other outcome measures. Vitamin B12
supplementation produced trends towards changes in anxiety and visual processing. Conclusions: Our results suggest that high-dose Vitamin B6
supplementation increases inhibitory GABAergic neural influences, which is consistent with its known role in the synthesis of GABA.
Human
Psychopharmacology: Clinical and Experimental, 37(6) : 1-16
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Vitamins and supplements
Fereydouni,
S., Forstmeier, S.
Previous research
demonstrated that spiritually sensitive psychotherapy is an effective treatment for clients with depression or anxiety, with outcomes equivalent to
secular control interventions. The goal of this study was to evaluate the efficacy of spiritually sensitive logotherapy intervention in the treatment
of depression, anxiety, and stress symptoms in university students in Iran. Sixty students with elevated depression symptoms (Beck Depression
Inventory II, BDI-II, 22 or greater) were randomly assigned to either a twelve-session group logotherapy programme or a control group. Results showed
that spiritually sensitive logotherapy significantly reduced depression, anxiety, and stress, and significantly more so than in the control group
(e.g. interaction effect for BDI-II: F = 56.8, p < 0.001, with a large effect size).
, 61(1) : 139-157
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Feeney, A., Hock, R. S., Fava, M., Hernandez-Ortiz, J. M., Iovieno,
N., Papakostas, G. I.
Background: There are few available antidepressants for pediatric Major
Depressive Disorder (MDD). The objective of this systematic review and meta-analysis was to review industry-funded studies of antidepressants in
children and adolescents with MDD, and to better understand the contribution of study design and placebo response to the findings of these studies.
Methods: Randomized, double-blind, placebo-controlled clinical trials that compared antidepressant with placebo for the acute treatment of MDD in
children and/or adolescents were selected. Estimates of the standardized mean difference (SMD) in change in Children's Depression Rating Scale-
Revised scores were pooled, after examining for heterogeneity. A random-effects meta-analysis was completed. Results: Thirty-four antidepressant-
placebo comparisons, involving 6161 subjects, were included. The SMD among all studies was 0.12 (CI 0.08, 0.17; p < 0.001), a very small effect size,
lower than that seen in studies of adults with MDD. When the meta-analysis was limited to studies with a low mean placebo response, the SMD increased
to 0.19 and further increased to 0.22 when studies with at least a 50% chance of receiving placebo were included. Limitations: Many studies focused
on older children and younger adolescents. Our findings may not reflect antidepressant efficacy in older adolescents. Conclusions: The modest SMD
identified in this analysis may reflect study design factors and the application of antidepressants developed for adults to pediatric patients. Given
the urgent clinical need for more pediatric MDD treatments, the influence of placebo response and the need for drug development tailored to this
population should be considered in pediatric MDD trial design. (PsycInfo Database Record (c) 2022 APA, all rights reserved)
, 305 : 55-
64
- Year: 2022
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Selective serotonin reuptake inhibitors (SSRIs), Serotonin-norepinephrine reuptake inhibitors
(SNRIs), Antidepressants
(any), Other antidepressants
Eseadi, C., Ilechukwu, L. C., Victor-Aigbodion, V., Sewagegn, A. A., Amedu, A. N.
BACKGROUND: This research was designed to investigate the management of
depression among undergraduate religious education students and identify the research implications for school-based religious intervention.\rMETHODS:
This research is a randomized controlled trial. The treatment condition had 34 undergraduate religious education students but 33 undergraduate
religious education students were in the control condition. The treatment process involved a 12-week application of religious rational emotive
behavior therapy (RREBT). With Beck's depression inventory, version 2 (BDI-II), data collection was made possible.\rRESULTS: Compared to students in
the control condition, undergraduate religious education students in the treatment condition demonstrated a significant drop in mean BDI-II scores at
post-test (F [1, 65] = 592.043, P < .05, eta2p = .90). The effect of RREBT among students in the treatment condition stayed consistent at 2 weeks
follow-up (F [1, 65] = 786.396, P < .05, eta2p = .92, DELTAR2 = .922).\rCONCLUSION: The effect of RREBT on depression treatment among undergraduate
religious education students was positive and can be consistent. The study results underscore the importance of expanding this treatment approach for
these undergraduate education students in Nigeria.
, 101(41) : e31034
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Edwards, E. J., Zec, D., Campbell, M., Hoorelbeke, K., Koster, E. H. W., Derakshan, N., Wynne, J.
Cognitive control training has gained traction as an intervention for reducing anxiety and depression vulnerability in
adults. There are, however, a limited number of studies investigating such training interventions for reducing symptomology of anxiety and depression
in children and adolescents. Thus, we aimed to provide a robust review and qualitative synthesis of the available research in young people. Twelve
articles met the inclusion criteria, and all were randomised control trials. Evidence of the efficacy of cognitive control training for relief of
symptoms are reported separately for anxiety, depression, and other related psychological factors, and on the basis of type of cognitive control
training paradigm. A lack of standardisation in relation to type of intervention, duration and context, outcome measures and population was observed.
Results are discussed in terms of these variations and recommendations for future research are provided.
, 300 : 158-
171
- Year: 2022
- Problem: Anxiety Disorders (any), Post Traumatic Stress Disorder, Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive remediation
therapy, Other Psychological Interventions
Du, Z., Zhang, X., Qin, H., Wang, R., Bai, Y., Yao, X.
Background: Taijiquan, as a physical and mental exercise, can improve the negative psychology of college students.
However, it is still controversial, and the optimal exercise dose of taijiquan to interfere with negative psychology has not been evaluated.
Objective(s): This study is aimed at systematically evaluating the effect of taijiquan therapy on improving negative psychological symptoms of
college students and its optimal intervention dose. Method(s): Search databases such as Web of Science, Embase, PubMed, CNKI, WFSD, etc. Collect
high-quality relevant RCT studies. After screening, extracting, coding and counting the data, a META analysis is done through Review Manage 5.3 and
Stata 15.0 software. PICOS established the eligibility criteria to select the studies as follows: (i) population - non-clinical of college students;
(ii) intervention - taijiquan intervention; (iii) comparison - taijiquan intervention group and regular physical activity group; (iv) outcomes -
depression, anxiety; and (v) study design - randomized controlled trial. Result(s): A total of 12 articles and 1,000 samples were included. All of
the participants are college students. Taijiquan therapy can significantly reduce the depression and anxiety symptoms of college students [SMD = -
0.53, 95% CI (-0.82, -0.23)], [SMD = -0.49, 95% CI (-0.90, -0.09)], with statistical significance (P < 0.05). Subgroup analysis shows that: there is
a precise focus on depression and anxiety symptoms. The intervention period is more than 12 weeks, and the best effect appears when people practice 3
times a week. The best single intervention time for depression symptoms is 60 min, and for anxiety symptoms 80-90 min. It is found that taijiquan
combined with mindfulness intervention can significantly reduce negative psychological symptoms like depression and anxiety of college students than
single taijiquan intervention. Funnel plot combined with sensitivity analysis, Begg, Egger test showed no publication bias. Conclusion(s): Taijiquan
intervention can effectively improve the negative psychological symptoms of college students, and it has great promotion value in colleges and
universities. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022314071. Copyright © 2022 Du, Zhang, Qin,
Wang, Bai and Yao.
Frontiers in Public Health, 10 : 1032266
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Mind-body exercises (e.g. yoga, tai chi, qigong)
Dippel, N., Szota, K., Cuijpers, P., Christiansen, H., Brakemeier, E. L.
PURPOSE: Depressive disorders in children and adolescents
have an enormous impact on their general quality of life. There is a clear need to effectively treat depression in this age group. Effects of
psychotherapy can be enhanced by involving caregivers. In our systematic review and meta-analysis, we examine for the first time the effects of
caregiver involvement in depression-specific interventions for children and adolescents. METHOD(S): We included randomized controlled trials
examining the effects of interventions for children and adolescents with depression involving their caregivers or families compared to interventions
without including caregivers. Primary outcome was the severity of childhood and adolescent depression. RESULT(S): Overall, 19 randomized controlled
trials could be included (N = 1553) that were highly heterogeneous regarding outcome measures or the extent of caregiver integration. We were able to
include k = 17 studies in our meta-analysis and find a small but significant effect for family-involved interventions against active control
conditions without family-involvement at post intervention (alpha = 0.05, d = 0.34; [0.07; 0.60]; p = .01). CONCLUSION(S): We detected an overall
significant but small effect of family/caregivers' involvement compared to control groups without it. Structured, guideline-based research is
urgently needed to identify for which children/adolescents with depression, under what circumstances, and in what form the family should be
effectively involved in their psychotherapy. Copyright © 2022 The Authors. Psychology and Psychotherapy: Theory, Research and Practice published by
John Wiley & Sons Ltd on behalf of The British Psychological Society.
, 14 :
- Year: 2022
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Family therapy, Other Psychological Interventions