Disorders - depressive disorders
Sang, H., Tan,
D.
The primary aim of this study was to evaluate the
effectiveness of a social skills training program for Chinese students' internalizing behavior disorders symptoms reduction. Additionally, the study
aimed to clarify whether the use of social skills training program would lead to better outcome than the use of daily usual program. Our RCT study
randomly assigned 29 students who were suspected of internalizing behavior disorders to an intervention group in which students received a
cognitive-behavioral approach-based social skills training program (n = 16) or to a control group with daily usual program during the period (n =
13). The analyses suggest that students receiving the social skills training program reported a significantly decrease of anxiety, depression and
withdrawal symptoms during the end of the intervention and follow-up interval than did students in the control group. Cognitive-behavioral approach-
based social skills interventions may help increase the sustainability of outcome after treatment for internalizing behavior disorders symptoms.
Copyright © 2018, Anka Publishers. All rights reserved.
NeuroQuantology, 16(5) : 104-109
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Skills training
Schleider,
J., Weisz, J.
Background: Single-session interventions (SSIs) show promise in the prevention and treatment of youth
psychopathology, carrying potential to improve the scalability and accessibility of youth psychological services. However, existing SSIs have
conferred greater benefits for youths with anxiety, compared to depression or comorbid problems, and their effects have generally waned over time-
particularly for follow-ups exceeding 3 months. Method: To help address these discrepancies, we tested whether a novel SSI teaching growth mindset of
personality (the belief that personality is malleable) could reduce depression and anxiety and strengthen perceived control in high-risk adolescents
(N = 96, ages 12-15). At baseline, youths were randomized to receive a 30-min, computer-guided growth mindset intervention or a supportive-therapy
control. Youths and parents reported youth anxiety and depressive symptoms, and youths reported their levels of perceived control, at baseline and
across a 9-month follow-up period. Results: Compared to the control program, the mindset intervention led to significantly greater improvements in
parent-reported youth depression (d = .60) and anxiety (d = .28), youth-reported youth depression (d = .32), and youth-reported perceived behavioral
control (d = .29) by 9-month follow-up. Intervention effects were nonsignificant for youth-reported anxiety, although 9-month effect sizes reached
the small-to-medium range (d = .33). Intervention group youths also experienced more rapid improvements in parent-reported depression, youth-reported
depression, and perceived behavioral control across the follow-up period, compared to control group youths. Conclusions: Findings suggest a
promising, scalable SSI for reducing internalizing distress in high-risk adolescents. (PsycINFO Database Record (c) 2018 APA, all rights
reserved)
Journal of Child Psychology and Psychiatry, 59(2) : 160-170
- Year: 2018
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Supportive
therapy, Other Psychological Interventions, Technology, interventions delivered using technology (e.g. online, SMS)
Singhal, M., Munivenkatappa, M., Kommu, J. V. S., Philip, M.
Subclinical depressive symptoms in adolescents are
associated with a host of impairments and constitute a risk factor for future depression. The aim of the present study was to study the efficacy of a
school-based group coping skills program for Indian adolescents with subclinical depression. Adolescents (n = 120) across two schools comprised the
intervention and control groups and were assessed at baseline, post-intervention, and 3 months no-contact follow-up. The intervention group
adolescents received the 8-weekly Coping Skills program in same-gender groups of 4-8 adolescents each, and the control group adolescents received one
interactive psycho-educatory session. The intervention group evidenced clinically significant reductions in depressive symptoms, negative cognitions,
and academic stress, and increased social problem solving and coping skills, at both post-intervention and follow-up. With regard to moderators,
initial levels of depressive symptoms and homework compliance were found to partially moderate the effect of intervention. No effects were found for
parental depression, gender, and age. The present study calls for future development and implementation of programs to address subclinical
psychopathology among adolescents in Indian schools. Copyright © 2018 Elsevier B.V.
Asian Journal of Psychiatry, 33 : 99-
104
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Skills training
Smith, H. L., Dillon, K.
H., Cougle, J. R.
Interpretation Bias Modification (IBM) is gaining attention in the literature as
an intervention that alters cognitive biases and reduces associated symptoms. Forty, primarily college-aged, non-treatment-seeking adults with major
depressive disorder (MDD) were randomly assigned to receive either IBM targeting hostile interpretation bias (IBM-H) or a healthy video control (HVC)
condition. Compared to those in HVC, participants in IBM-H reported more benign interpretations and fewer hostile interpretations at posttreatment.
No difference in depressive interpretation bias was found between groups at posttreatment. IBM-H led to improved anger control at posttreatment and
follow-up compared to HVC, though no effects of condition were found on trait anger or depressive symptoms. The IBM-H group perceived their treatment
as less credible than the HVC group. For individuals with high expectancy of treatment success, IBM-H led to lower posttreatment depressive symptoms
compared to HVC, while findings trended in the opposite direction for those with low expectancy of success. Overall, these preliminary findings point
to boundary conditions for the efficacy of IBM protocols for anger and depression and potential improvements to be made to future IBM protocols.
Copyright © 2017
Behavior Therapy, 49(2) : 198-
211
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Attention/cognitive bias
modification
Valenzuela, F., Lock, J., LeGrange, D., Bohon, C.
This study examined the effect of family-based treatment
for bulimia nervosa (FBT-BN) and cognitive behavioral therapy for adolescents (CBT-A) on depressive symptoms and self-esteem in adolescents with BN.
Data were collected from 110 adolescents, ages 12-18, who met Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition, text revision
criteria for BN or partial BN. Participants were randomly assigned to FBT-BN or CBT-A and completed measures of depressive symptoms and self-esteem
before and after treatment and at 6- and 12-month follow-up assessments. Depressive symptoms and self-esteem significantly improved in both
treatments, and neither treatment appeared superior on these clinical outcomes. Parents often worry whether FBT-BN addresses comorbid depressive
symptoms and low self-esteem. Our findings address this concern, as they demonstrate that FBT-BN does not differ from CBT-A in improving depressive
symptoms and self-esteem, and both treatments result in symptom improvement. These findings can help clinicians guide families to choose a treatment
that addresses BN and depressive symptoms and low self-esteem. Copyright © 2018 John Wiley & Sons, Ltd and Eating Disorders Association.
European Eating Disorders
Review, 26(3) : 253-258
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Family therapy
Valizadeh, R., Shohani, M., Tavan, H.
Objectives: The
current study aimed at analyzing the effect of transcranial direct current stimulation (TDCS) on reduction of depression symptoms in patients
admitted to public, educational, and private hospitals in Ilam, Iran. Methods: In the current clinical trial, pre-tests and post-tests were used to
analyze data. The study population consisted of patients diagnosed with depression admitted to public, educational, and private hospitals of Ilam.
After explaining the study objectives, 40 patients agreed to cooperate. The convenience sampling method was used in the current study through which
patients were selected randomly and allocated into 2 groups of 10 and 20 stimulation sessions, respectively. The Beck depression inventory was used
to collect data. The t test and Pearson correlation test were used in hypothesis assessment procedure. Results: The results of the current study
revealed that TDCS reduced depression in the studied patients. Conclusions: The duration of electrical current pulses to the brain is associated with
the reduction of depression symptoms in patients with depression. No study demonstrated compatibility and incompatibility with this hypothesis. The
counselling centers, institutes, university and other institutions can benefit from the results of the current and other similar ones. Copyright ©
2018, Archives of Neuroscience.
Archives of Neuroscience, 5 (1) (no
pagination)(e60001) :
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Other biological interventions
Vesco, A. T., Young, A. S., Arnold, L., Fristad, M. A.
Background:
Improvements in executive functioning (EF) may lead to improved quality of life and lessened functional impairment for children with mood disorders.
The aim was to assess the impact of omega-3 supplementation (OMEGA3) and psychoeducational psychotherapy (PEP), each alone and in combination, on EF
in youth with mood disorders. We completed secondary analyses of two randomized controlled trials (RCTs) of OMEGA3 and PEP for children with
depression and bipolar disorder. Methods: Ninety-five youths with depression or bipolar disorder not otherwise specified/cyclothymic disorder were
randomized in 12-week RCTs. Two capsules (OMEGA3 or placebo) were given twice daily (1.87 g OMEGA3 total daily, mostly eicosapentaenoic acid).
Families randomized to PEP participated in twice-weekly 50-min sessions. Analyses assess impact of interventions on the Behavior Rating Inventory of
Executive Functioning (BRIEF) parent-report Global Executive Composite (GEC) and two subscales, Behavior Regulation (BRI) and Metacognition (MI)
Indices. Intent-to-treat repeated measures ANOVAs, using multiple imputation for missing data, included all 95 randomized participants. Trials were
registered with www.clinicaltrials.gov, NCT01341925 & NCT01507753. Results: Participants receiving OMEGA3 (aggregating combined and monotherapy)
improved significantly more than aggregated placebo on GEC (p = .001, d = .70), BRI (p = .004, d = .49), and MI (p = .04, d = .41). OMEGA3 alone (d =
.49) and combined with PEP (d = .67) each surpassed placebo on GEC. Moderation by attention-deficit/ hyperactivity disorder (ADHD) comorbidity was
nonsignificant although those with ADHD showed nominally greater gains. PEP monotherapy had negligible effect. Conclusions: Decreased impairment in
EF was associated with OMEGA3 supplementation in youth with mood disorders. Research examining causal associations of OMEGA3, EF, and mood symptoms
is warranted. (PsycINFO Database Record (c) 2018 APA, all rights reserved)
Journal of Child Psychology and Psychiatry, 59(6) : 628-
636
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Psychoeducation, Fish oil (Omega-3 fatty acids), Omega 3 fatty
acids (e.g. fish oil, flax oil)
Weihs, K. L., Murphy, W., Abbas, R., Chiles, D., England, R. D., Ramaker, S., Wajsbrot, D. B.
Objectives: To evaluate the short-term efficacy and
safety of desvenlafaxine (25-50 mg/d) compared with placebo in children and adolescents with major depressive disorder (MDD). Methods: Outpatient
children (7-11 years) and adolescents (12-17 years) who met DSM-IV-TR criteria for MDD and had screening and baseline Children's Depression Rating
Scale-Revised (CDRS-R) total scores >40 were randomly assigned to 8-week treatment with placebo, desvenlafaxine (25, 35, or 50 mg/d based on baseline
weight), or fluoxetine (20 mg/d). The primary efficacy endpoint was change from baseline in CDRS-R total score at week 8, analyzed using a mixed-
effects model for repeated measures. Secondary efficacy endpoints included week 8 Clinical Global Impressions-Severity, Clinical Global Impressions-
Improvement (CGI-I), and response (CGI-I <= 2). Safety assessments included adverse events, physical and vital sign measurements, laboratory
evaluations, electrocardiogram, and the Columbia-Suicide Severity Rating Scale. Results: The safety population included 339 patients (children, n =
130; adolescents, n = 209). The primary endpoint, change from baseline in CDRS-R total score at week 8, did not statistically separate from placebo,
for either desvenlafaxine (adjusted mean [standard error] change, -22.6 [1.17]) or fluoxetine (-24.8 [1.17]; placebo, -23.1 [1.18]). Week 8 CGI-I
response rates were significantly greater for fluoxetine (78.2%; p = 0.017) than for placebo (62.6%); desvenlafaxine (68.7%) did not differ from
placebo. Other secondary outcomes were consistent with those obtained with CDRS-R. Rates of treatment-emergent adverse events were comparable among
treatment groups (desvenlafaxine, 60.0%; placebo, 70.5%; and fluoxetine, 64.3%). Conclusion: Desvenlafaxine did not demonstrate efficacy for treating
MDD in children and adolescents in this trial. Because neither desvenlafaxine nor the reference medication, fluoxetine, demonstrated a statistically
significant difference from placebo on the primary endpoint, this was considered a failed trial and no efficacy conclusions can be drawn.
Desvenlafaxine 25-50 mg/d was generally safe and well tolerated in children and adolescents in this study. Copyright © Karen L. Weihs et al. 2017;
Published by Mary Ann Liebert, Inc.
Journal of Child and Adolescent Psychopharmacology, 28(1) : 36-
46
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Selective serotonin reuptake inhibitors (SSRIs), Serotonin-norepinephrine reuptake inhibitors
(SNRIs), Antidepressants
(any)
Wunram, H. L., Hamacher, S., Hellmich, M., Volk, M., Janicke, F., Reinhard, F., Bloch, W., Zimmer, P., Graf, C., Schonau, E., Lehmkuhl, G., Bender,
S., Fricke, O.
There is growing evidence for the effectiveness of
exercise in the treatment of adult major depression. With regard to adolescents, clinical trials are scarce. Due to the inherent symptoms of
depression (lack of energy, low motivation to exercise), endurance training forms could be too demanding especially in the first weeks of treatment.
We hypothesized that an easy-to-perform passive muscular training on a whole body vibration (WBV) device has equal anti-depressive effects compared
to a cardiovascular training, both administered as add-ons to treatment as usual (TAU). Secondly, we presumed that both exercise interventions would
be superior in their response, compared to TAU. In 2 years 64 medication-naive depressed inpatients aged 13-18, were included. Both exercise groups
fulfilled a supervised vigorous training for 6 weeks. Depressive symptoms were assessed by self-report (\"Depressions Inventar fur Kinder und
Jugendliche\"-DIKJ) before intervention and after weeks 6, 14 and 26. Compared to TAU, both groups responded earlier and more strongly measured by
DIKJ scores, showing a trend for the WBV group after week 6 (p = 0.082). The decrease became statistically significant for both intervention groups
after week 26 (p = 0.037 for ergometer and p = 0.042 for WBV). Remission rates amounted to 39.7% after week 6 and 66% after week 26, compared to 25%
after week 26 in TAU. These results provide qualified support for the effectiveness of exercise as add-on treatment for medication-naive depressed
adolescents. The present results are limited by the not randomized control group. Copyright © 2017, Springer-Verlag GmbH Germany.
European Child and Adolescent Psychiatry, 27(5) : 645-
662
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Physical activity, exercise, Other complementary & alternative
interventions
Yang,
X., Zhao, J., Chen, Y., Zu, S.
BACKGROUND: Depressive disorder was
associated with dysfunctional self-regulation. The current study attempted to design and test a comprehensive self-control training (CSCT) program
with an overall emphasis on behaviral activation in depressed Chinese college students.\rMETHODS: Participants included 74 students who had diagnosed
with major depression, they were randomly assigned to one of the two groups: intervention group (n=37), and control group (n=37). The intervention
participants received an eight-week CSCT and four-month follow-up consolidation program, as compared to the control group who received only pre-
post-and-follow-up measurements. All participants measured Beck Depression Inventory (BDI-II) and Self-control Scale (SCS) at three time points:
baseline, post-training, and four-month follow-up.\rRESULTS: The dropout rates were 6 (8.1%) in the intervention group and 3 (4.1%) in the control
group at the end of six-month intervention. The general linear model repeated measures analysis of variance revealed that comparing with the control
group, the intervention group participants had more increase in their trait self-control score, at the meantime, their depressive symptoms had
significantly improved. Univariate and logistic regression analyses revealed that participants with milder baseline depressive symptoms were more
likely to benefit from CSCT interventions; depression improvement was also associated with the number of sessions attended.\rLIMITATIONS: The main
limitation was related to the small sample size which consisted of college students who were relatively young and well educated.\rCONCLUSIONS: The
current study demonstrates that CSCT program could temporarily enhance self-control capacity as well as improve depressive symptoms; participants who
are mildly to moderately depressed, and who could adhere to the training protocol are more likely to benefit from the intervention.
Journal of Affective Disorders, 226 : 251-260
- Year: 2018
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any)
Abuwalla, Z., Clark, M. D., Burke, B., Tannenbaum, V., Patel, S., Mitacek, R., Gladstone, T., Van-Voorhees, B.
Introduction This rapid review identifies and summarizes the effectiveness of
preventative telemental health interventions. It investigates studies conducted between 2010 and 2016 that improve mood and anxiety with long-term
follow-up. Methods A literature search of three major databases was performed by four reviewers. After citation tracing, 3604 studies were
discovered, and twenty of these met the inclusion criteria. Data from the papers were abstracted, assessed for quality, and effect sizes were
calculated. Results Salient information was discussed using the Behavioural Vaccine Model of mental illness prevention. This included key concepts
such as efficacy, duration of benefits, sociocultural relevance, professional guidance, peer-to-peer support, adherence, delivery and safety.
Conclusion This review suggests there are clear prolonged benefits to using technology in youth mental illness prevention. Although this is a rapidly
growing area of investigation in countries around the globe, there is still a dearth of research with long-term follow-up. Future studies should aim
to boost engagement by increasing motivational guidance in order to recruit at-risk youth of all demographics into these promising intervention
programs. Copyright © 2017
Internet
Interventions, 11 : 20-29
- Year: 2018
- Problem: Anxiety Disorders (any), Obsessive Compulsive Disorder, Post Traumatic Stress Disorder, Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Skills training, Attention/cognitive bias
modification, Technology, interventions delivered using technology (e.g. online, SMS)
Bailey, A.
P., Hetrick, S. E., Rosenbaum, S., Purcell, R., Parker, A. G.
We aimed to establish the treatment effect of
physical activity for depression in young people through meta-analysis. Four databases were searched to September 2016 for randomised controlled
trials of physical activity interventions for adolescents and young adults, 12-25 years, experiencing a diagnosis or threshold symptoms of
depression. Random-effects meta-analysis was used to estimate the standardised mean difference (SMD) between physical activity and control
conditions. Subgroup analysis and meta-regression investigated potential treatment effect modifiers. Acceptability was estimated using dropout.
Trials were assessed against risk of bias domains and overall quality of evidence was assessed using GRADE criteria. Seventeen trials were eligible
and 16 provided data from 771 participants showing a large effect of physical activity on depression symptoms compared to controls (SMD = -0.82, 95%
CI = -1.02 to -0.61, p < 0.05, I2 = 38%). The effect remained robust in trials with clinical samples (k = 5, SMD = -0.72, 95% CI = -1.15 to -0.30),
and in trials using attention/activity placebo controls (k = 7, SMD = -0.82, 95% CI = -1.05 to -0.59). Dropout was 11% across physical activity arms
and equivalent in controls (k = 12, RD = -0.01, 95% CI = -0.04 to 0.03, p = 0.70). However, the quality of RCT-level evidence contributing to the
primary analysis was downgraded two levels to LOW (trial-level risk of bias, suspected publication bias), suggesting uncertainty in the size of
effect and caution in its interpretation. While physical activity appears to be a promising and acceptable intervention for adolescents and young
adults experiencing depression, robust clinical effectiveness trials that minimise risk of bias are required to increase confidence in the current
finding. The specific intervention characteristics required to improve depression remain unclear, however best candidates given current evidence may
include, but are not limited to, supervised, aerobic-based activity of moderate-to-vigorous intensity, engaged in multiple times per week over eight
or more weeks. Further research is needed. (Registration: PROSPERO-CRD 42015024388).
Psychological Medicine, 48(7) : 1068-
1083
- Year: 2018
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Physical activity, exercise