Disorders - depressive disorders
Pu, J., Zhou, X., Liu,
L., Zhang, Y., Yang, L., Yuan, S., Zhang, H., Han, Y., Zou, D., Xie, P.
In this study, we evaluate the efficacy and safety of interpersonal psychotherapy (IPT) for
adolescents with depression. We searched our existing database and electronic databases, including PubMed, Cochrane, EMBASE, PsycINFO, Web of
Science, and CINAHL databases (from inception to May 2016). We included randomized controlled trials comparing IPT with various control conditions,
including waitlist, psychological placebo, treatment as usual, and no treatment, in adolescents with depression. Finally, we selected seven studies
comprising 538 participants comparing IPT with three different control conditions. Pooled analyses suggested that IPT was significantly more
effective than control conditions in reducing depressive symptoms at post-treatment and follow-up, and increasing the response/remission rate at
post-treatment. IPT was also superior to control conditions for all-cause discontinuation and quality of life/functioning improvement outcomes.
However, there was no evidence that IPT reduces the risk of suicide from these data. Meta-analysis demonstrated publication bias for primary
efficacy, while the adjusted standardized mean difference using the trim-and-fill method indicated IPT was still significantly superior to the
control conditions. Current evidence indicates IPT has a superior efficacy and acceptability compared with control conditions in treating adolescents
with depression.
Psychiatry Research, 253 : 226-
232
- Year: 2017
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Interpersonal therapy (IPT)
Nardi, B., Massei, M., Arimatea, E., Moltedo-Perfetti, A.
Depression is among the most common psychological
disorders of adolescents. Its management is based on pharmacological treatment, psychological therapy, or a combination thereof. Cognitive behavioral
therapy (CBT) is the most extensively tested intervention for adolescent depression. A PubMed search was conducted for randomized controlled trials
(RCT) of the efficacy of CBT in treating adolescents with depressive symptoms published in 2005-2015. Keywords were \"cognitive behavioral therapy\",
\"group therapy\", \"depression\" and \"adolescent\". Of the 23 papers that were retrieved, only six met all inclusion criteria. Three of them
reported a significant reduction in depressive symptom severity after either individual or group (G)-CBT compared with the control group, even with a
small number of CBT sessions (six rather than 10-12), with a medium or medium-to-large effect size. One study reported improved self-awareness and a
significantly greater increase in perceived friend social support compared with bibliotherapy and check with brochure. Two studies reported clinical
symptom reduction without significant differences compared with the control group (activity contrast). This review highlighted primarily that very
few RCT have applied CBT in adolescents; moreover, it confirmed the effectiveness of G-CBT, especially as psychotherapy, although it was not always
superior to other interventions (e.g. other activities in prevention programs). Comparison showed that G-CBT and group interpersonal psychotherapy
were both effective in reducing depressive symptoms. Successful G-CBT outcomes were related to the presence of peers, who were an important source of
feedback and support to observe, learn, and practice new skills to manage depressive symptoms and improve social-relational skills. Copyright © 2017
Walter de Gruyter GmbH, Berlin/Boston.
International Journal of Adolescent Medicine and Health, 29 (3) (no
pagination)(20150080) :
- Year: 2017
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT)
ODriscoll, M., Byrne,
S., McGillicuddy, A., Lambert, S., Sahm, L. J.
Health and social care undergraduate students experience
stress due to high workloads and pressure to perform. Consequences include depression and burnout. Mindfulness may be a suitable way to reduce stress
in health and social care degree courses. The objective of this systematic review is to identify and critically appraise the literature on the
effects of Mindfulness-Based Interventions for health and social care undergraduate students. PubMed, EMBASE, Psych Info, CINAHL, The Cochrane
Library and Academic Search Complete were searched from inception to 21st November 2016. Studies that delivered Mindfulness-Based Stress Reduction,
Mindfulness-Based Cognitive Therapy, or an intervention modelled closely on these, to health or social care undergraduate students were included.
Eleven studies, representing medicine, nursing and psychology students met the inclusion criteria. The most commonly used measurement tools were; the
Five Facet Mindfulness Questionnaire and the General Health Questionnaire. Short term benefits relating to stress and mood were reported, despite all
but one study condensing the curriculum. Gender and personality emerged as factors likely to affect intervention results. Further research with
long-term follow-up is required to definitively conclude that mindfulness is an appropriate intervention to mentally prepare health and social care
undergraduate students for their future careers.
Psychology, Health &
Medicine, 22(7) : 851-865
- Year: 2017
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Mindfulness based
therapy
McConville, J., McAleer, R., Hahne, A.
BACKGROUND: High levels of
stress have been identified in medical students and increasingly in other health profession student population groups. As stress can affect
psychological well-being and interfere with learning and clinical performance, there is a clear argument for universities to include health
professional student well-being as an outcome in core curriculum. Mindfulness training is a potential construct to manage stress and enhance academic
success.\rOBJECTIVES: The aims of this systematic review were to assess the effectiveness of mindfulness training in medical and other health
professional student population groups and to compare the effectiveness of the different mindfulness-based programs.\rDATA SOURCES: A literature
search was completed using The Cochrane library, Medline, Cinahl, Embase, Psychinfo, and ERIC (proquest) electronic databases from inception to June
2016. Randomized and non-randomized controlled trials were included. Of the potential 5355 articles, 19 met the inclusion criteria.\rSTUDY SELECTION
PARTICIPANTS AND INTERVENTIONS: Studies focused on medical (n = 10), nursing (n = 4), social work (n = 1), psychology (n = 1), and medical plus other
health (n = 3) students. Interventions were based on mindfulness.\rDATA EXTRACTION: The 19 studies included 1815 participants. Meta-analysis was
performed evaluating the effect of mindfulness training on mindfulness, anxiety, depression, stress, mood, self-efficacy, and empathy. The effect of
mindfulness on academic performance was discussed.\rDATA SYNTHESIS AND CONCLUSIONS: Mindfulness-based interventions decrease stress, anxiety, and
depression and improve mindfulness, mood, self-efficacy, and empathy in health profession students. Due to the range of presentation options,
mindfulness training can be relatively easily adapted and integrated into health professional training programs.
Explore: The Journal of Science & Healing, 13(1) : 26-
45
- Year: 2017
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Psychological Interventions
(any), Mindfulness based
therapy, Meditation, Mind-body exercises (e.g. yoga, tai chi, qigong)
Midgley,
N., OKeeffe, S., French, L., Kennedy, E.
While
the evidence base for psychodynamic therapy with adults is now quite substantial, there is still a lack of research evaluating the effectiveness of
psychodynamic therapies with children and young people. Those studies that have been carried out are also not widely known in the field. To help
address the second point, in 2011, we carried out a review of the evidence base for psychodynamic psychotherapy for children and adolescents, which
identified 35 studies which together provided some preliminary evidence for this treatment for a range of childhood disorders. The present study is
an updated review, focusing on research published between March 2011 and November 2016. During this period, 23 additional studies were published, of
which 5 were reports on randomised controlled trials, 3 were quasi-experimental controlled studies and 15 were observational studies. Although most
studies covered children with mixed diagnoses, there were a number of studies examining specific diagnostic groups, including children with
depression, anxiety and disruptive disorders. whilst the quality of studies was mixed, some were well-designed and reported, and overall indicated
promising findings. Nevertheless, further high-quality research is needed in order to better understand the effectiveness of psychodynamic
psychotherapy across a range of different disorders, and to ensure that services can provide a range of evidence-based treatments for children and
young people. Copyright © 2017 Association of Child Psychotherapists.
Journal of
Child Psychotherapy, 43(3) : 307-329
- Year: 2017
- Problem: Anxiety Disorders (any), Depressive Disorders, Suicide or self-harm behaviours (excluding non-suicidal self-harm)
- Type: Systematic reviews
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Psychodynamic/Psychoanalysis
Morina, N., Malek, M., Nickerson, A., Bryant, R. A.
BackgroundThe majority of survivors of mass violence
live in low- and middle-income countries (LMICs).AimsTo synthesise empirical findings for psychological interventions for children and
adolescents with post-traumatic stress disorder (PTSD) and/or depression in LMICs affected by mass violence.MethodRandomised controlled trials
with children and adolescents with symptoms of PTSD and/or depression in LMICs were identified. Overall, 21 812 records were found through July 2016
in the Medline, PsycINFO and PILOTS databases; 21 met the inclusion criteria and were reviewed according to recommended
guidelines.ResultsTwenty-one studies were included. Active treatments for PTSD yielded large pre-treatment to post-treatment changes (g =
1.15) and a medium controlled effect size (g = 0.57). Effect sizes were similar at follow-up. Active treatments for depression produced small to
medium effect sizes. Finally, after adjustment for publication bias, the imputed uncontrolled and controlled effect sizes for PTSD were medium and
small respectively.ConclusionsPsychological interventions may be effective in treating paediatric PTSD in LMICs. It appears that more targeted
approaches are needed for depressive responses.
British Journal of
Psychiatry, 210(4) : 247-254
- Year: 2017
- Problem: Post Traumatic Stress Disorder, Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any)
Journot-Reverbel, K., Raynaud, J. P., Bui, E., Revet, A.
Though many different interventions are proposed for suicide-
bereaved children and adolescents, few data exist concerning their efficiency. This literature review focused on psychosocial interventions
specifically targeting children and adolescents bereaved by suicide to try to provide some validate therapeutic guidelines propositions for
clinicians. We only found two articles specifically targeting children or adolescents: both of them seemed to show some efficacy in reducing some
psychosocial variables (anxiety, depression...) in suicide-bereaved children but results were limited by methodological problems. This review failed
to provide evidence-based guidelines propositions for suicide-bereaved children and underline the crucial need for research in this field. Copyright
© 2017 Elsevier Ireland Ltd
Psychiatry Research, 250 : 253-
255
- Year: 2017
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Lee, Y. Y., Barendregt, J. J., Stockings, E. A., Ferrari, A.
J., Whiteford, H. A., Patton, G. A., Mihalopoulos, C.
Aims. School-based psychological interventions encompass: universal
interventions targeting youth in the general population; and indicated interventions targeting youth with subthreshold depression. This study aimed
to: (1) examine the population cost-effectiveness of delivering universal and indicated prevention interventions to youth in the population aged 11-
17 years via primary and secondary schools in Australia; and (2) compare the comparative cost-effectiveness of delivering these interventions using
face-to-face and internet-based delivery mechanisms. Methods. We reviewed literature on the prevention of depression to identify all interventions
targeting youth that would be suitable for implementation in Australia and had evidence of efficacy to support analysis. From this, we found evidence
of effectiveness for the following intervention types: universal prevention involving group-based psychological interventions delivered to all
participating school students; and indicated prevention involving group-based psychological interventions delivered to students with subthreshold
depression. We constructed a Markov model to assess the cost-effectiveness of delivering universal and indicated interventions in the population
relative to a 'no intervention' comparator over a 10-year time horizon. A disease model was used to simulate epidemiological transitions between
three health states (i.e., healthy, diseased and dead). Intervention effect sizes were based on meta-analyses of randomised control trial data
identified in the aforementioned review; while health benefits were measured as Disability-adjusted Life Years (DALYs) averted attributable to
reductions in depression incidence. Net costs of delivering interventions were calculated using relevant Australian data. Uncertainty and sensitivity
analyses were conducted to test model assumptions. Incremental cost-effectiveness ratios (ICERs) were measured in 2013 Australian dollars per DALY
averted; with costs and benefits discounted at 3%. Results. Universal and indicated psychological interventions delivered through face-to-face
modalities had ICERs below a threshold of 50 000 per DALY averted. That is, 7350 per DALY averted (95% uncertainty interval (UI): dominates - 23 070)
for universal prevention, and 19 550 per DALY averted (95% UI: 3081-56 713) for indicated prevention. Baseline ICERs were generally robust to changes
in model assumptions. We conducted a sensitivity analysis which found that internet-delivered prevention interventions were highly cost-effective
when assuming intervention effect sizes of 100 and 50% relative to effect sizes observed for face-to-face delivered interventions. These results
should, however, be interpreted with caution due to the paucity of data. Conclusions. School-based psychological interventions appear to be cost-
effective. However, realising efficiency gains in the population is ultimately dependent on ensuring successful system-level implementation.
Copyright © Cambridge University Press 2016.
Epidemiology and Psychiatric Sciences, 26(5) : 545-
564
- Year: 2017
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Self-help, Technology, interventions delivered using technology (e.g. online, SMS)
Locher, C., Koechlin,
H., Zion, S. R., Werner, C., Pine, D. S., Kirsch, I., Kessler, R. C., Kossowsky, J.
IMPORTANCE: Depressive disorders (DDs), anxiety disorders (ADs), obsessive-compulsive disorder
(OCD), and posttraumatic stress disorder (PTSD) are common mental disorders in children and adolescents. OBJECTIVE: To examine the relative efficacy
and safety of selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and placebo for the treatment of
DD, AD, OCD, and PTSD in children and adolescents. DATA SOURCES: PubMed, EMBASE, PsycINFO, Web of Science, and Cochrane Database from inception
through August 7, 2016. STUDY SELECTION: Published and unpublished randomized clinical trials of SSRIs or SNRIs in youths with DD, AD, OCD, or PTSD
were included. Trials using other antidepressants (eg, tricyclic antidepressants, monoamine oxidase inhibitors) were excluded. DATA EXTRACTION AND
SYNTHESIS: Effect sizes, calculated as standardized mean differences (Hedges g) and risk ratios (RRs) for adverse events, were assessed in a random-
effects model. MAIN OUTCOMES AND MEASURES: Primary outcomes, as defined by authors on preintervention and postintervention data, mean change data,
and adverse event data, were extracted independently by multiple observers following PRISMA guidelines. RESULTS: Thirty-six trials were eligible,
including 6778 participants (3484 [51.4%] female; mean [SD] age, 12.9 [5.1] years); 17 studies for DD, 10 for AD, 8 for OCD, and 1 for PTSD. Analysis
showed that SSRIs and SNRIs were significantly more beneficial compared with placebo, yielding a small effect size (g = 0.32; 95% CI, 0.25-0.40; P <
.001). Anxiety disorder (g = 0.56; 95% CI, 0.40-0.72; P < .001) showed significantly larger between-group effect sizes than DD (g = 0.20; 95% CI,
0.13-0.27; P < .001). This difference was driven primarily by the placebo response: patients with DD exhibited significantly larger placebo responses
(g = 1.57; 95% CI, 1.36-1.78; P < .001) compared with those with AD (g = 1.03; 95% CI, 0.84-1.21; P < .001). The SSRIs produced a relatively large
effect size for ADs (g = 0.71; 95% CI, 0.45-0.97; P < .001). Compared with participants receiving placebo, patients receiving an antidepressant
reported significantly more treatment-emergent adverse events (RR, 1.07; 95% CI, 1.01-1.12; P = .01 or RR, 1.49; 95% CI, 1.22-1.82; P < .001,
depending on the reporting method), severe adverse events (RR, 1.76; 95% CI, 1.34-2.32; P < .001), and study discontinuation due to adverse events
(RR, 1.79; 95% CI, 1.38-2.32; P < .001). CONCLUSIONS AND RELEVANCE: Compared with placebo, SSRIs and SNRIs are more beneficial than placebo in
children and adolescents; however, the benefit is small and disorder specific, yielding a larger drug-placebo difference for AD than for other
conditions. Response to placebo is large, especially in DD. Severe adverse events are significantly more common with SSRIs and SNRIs than placebo.
Copyright © 2017 American Medical Association. All rights reserved.
JAMA Psychiatry, 74(10) : 1011-
1020
- Year: 2017
- Problem: Anxiety Disorders (any), Obsessive Compulsive Disorder, Post Traumatic Stress Disorder, Depressive Disorders
- Type: Systematic reviews
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Selective serotonin reuptake inhibitors (SSRIs), Serotonin-norepinephrine reuptake inhibitors
(SNRIs), Antidepressants
(any)
Gualano, M. R., Bert, F., Martorana, M., Voglino, G., Andriolo, V., Thomas, R., Gramaglia, C., Zeppegno, P., Siliquini, R.
Objective Literature shows bibliotherapy can be helpful for
moderate depression treatment. The aim of this systematic review is to verify the long-term effects of bibliotherapy. Methods After bibliographic
research, we included RCTs articles about bibliotherapy programme treatment of depression published in English language between 1990 and July 2017.
All RCTs were assessed with Cochrane's Risk of Bias tool. Results Ten articles (reporting 8 studies involving 1347 subjects) out of 306 retrieved
results were included. All studies analyze the effects of bibliotherapy after follow-up periods ranging from 3 months to 3 years and show quiet good
quality in methods and analyses. The treatment was compared to standard treatments or no intervention in all studies. After long-term period follow-
ups, six studies, including adults, reported a decrease of depressive symptoms, while four studies including young people did not show significant
results. Conclusion Bibliotherapy appears to be effective in the reduction of adults depressive symptoms in the long-term period, providing an
affordable prompt treatment that could reduce further medications. The results of the present review suggest that bibliotherapy could play an
important role in the treatment of a serious mental health issue. Further studies should be conducted to strengthen the evidence of bibliotherapy's
efficacy. Copyright © 2017 Elsevier Ltd
Clinical Psychology
Review, 58 : 49-58
- Year: 2017
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Self-help
Zemestani, M., Imani, M., Ottaviani, C.
High rates of comorbid depression and anxiety often complicate psychological
interventions. The current preliminary study was designed to examine the efficacy of a unified and transdiagnostic model based on emotion regulation
skills for patients with comorbid depression and anxiety. Forty-three participants with a diagnosis of major depression and varying levels of
comorbid anxiety symptoms were randomly assigned to either a unified and transdiagnostic treatment group (UP; n = 20) or a wait-list control group (n
= 23). The treatment group received 14 weekly UP sessions. Scores on the Beck Depression Inventory-II, Beck Anxiety Inventory, and Emotion Regulation
Questionnaire were used as outcome measures. Data provided preliminary evidence that UP can be effective in reducing depressive and anxiety symptoms
and in improving the use of effective emotion regulation strategies up to 3 months. Present results support the implementation of UP as a beneficial
group treatment for patients with comorbid depressive and anxiety symptoms. (PsycINFO Database Record (c) 2018 APA, all rights reserved)
International
Journal of Cognitive Therapy, 10(2) : 175-185
- Year: 2017
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT)
Zou,
Y., Li, H., Shi, C., Lin, Y., Zhou, H., Zhang, J.
The present study aimed to explore the effects of psychological pain theory-based cognitive therapy (PPTBCT) on suicide among
depressed patients, compared with a control group who received usual psychological care (UPC). The sample consisted of 32 depressed patients and 32
healthy control subjects. All participants completed the Beck Scale for Suicide Ideation (BSI), Beck Depression Inventory, Three-Dimensional
Psychological Pain Scale (TDPPS), and Problem Solving Inventory(PSI), and Automatic Thoughts Questionnaire (ATQ). All measures differed significantly
between depressed patients and healthy controls. Then clinical participants were assigned randomly to the PPTBCT (n=19) and control (n=13) groups.
During the 8-week intervention, scores related to depression, suicidal ideation, psychological pain, and automatic thoughts were decreased in both
groups at the post-intervention and 4-week follow-up time points, compared with pre-intervention scores. BSI scores remained low at follow up and did
not differ significantly from post-intervention scores in the PPTBCT group, but were significantly higher at follow up than at post-intervention in
the control group. PPTBCT may effectively reduce suicide risk in patients with major depressive disorder, although the effects of its application
need to be confirmed.
Psychiatry Research, 249 : 23-
29
- Year: 2017
- Problem: Depressive Disorders, Suicide or self-harm behaviours (excluding non-suicidal self-harm), Suicide or self-harm with comorbid mental disorder
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT)