Disorders - depressive disorders
Cruwys, Tegan, Haslam, Catherine, Rathbone, Joanne A., Williams, Elyse, Haslam, S., Walter, Zoe C.
Background: Depression treatments are typically
less effective for young people than for adults. However, treatments rarely target loneliness, which is a key risk factor in the onset, maintenance
and development of depression. Aims: This study evaluated the efficacy of a novel loneliness intervention, Groups 4 Health (G4H), relative to the
best-practice treatment of cognitive-behavioural therapy (CBT) in reducing loneliness and depression over a 12-month period (Australian New Zealand
Clinical Trial Registry: ACTRN12618000440224). Method: The study was a phase 3 randomised non-inferiority trial comparing G4H with dose-controlled
group CBT. Participants were 174 people aged 15-25 years experiencing loneliness and clinically significant symptoms of depression, who were not in
receipt of adjunct treatment. Participants were recruited from mental health services in Southeast Queensland, Australia. Randomisation was conducted
using computer software. Follow-up assessments and statistical analyses were masked to allocation. Both interventions consisted of five 75 min
group-based psychotherapy sessions. The primary outcomes were depression and loneliness, with a non-inferiority margin of 2.20 for depression.
Results: The trial enrolled 174 participants between 24 April 2018 and 25 May 2019, with 84 in the G4H condition and 90 in the CBT condition. All
randomised participants were included in the intention-to-treat analyses (n = 174). The pre-post effect sizes for depression were dG4H = -0.71 and
dCBT = -0.91. For loneliness, they were dG4H = -1.07 and dCBT = -0.89. At 12-month follow-up, the absolute difference between groups on depression
was 1.176 (95% CI -1.94 to 4.29) and on loneliness it was -0.679 (95% CI -1.43 to 0.07). No adverse effects were observed. Conclusions: G4H was non-
inferior to CBT for depression and showed a slight advantage over CBT for loneliness that emerged after treatment completion. (PsycInfo Database
Record (c) 2022 APA, all rights reserved)
, 220(3) : 140-147
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Other Psychological Interventions
Costello, M. A., Nagel, A.
G., Hunt, G. L., Rivens, A. J., Hazelwood, O. A., Pettit, C., Allen, J. P.
This randomized
controlled trial examined the impact of The Connection Project, an experiential, relationship-focused intervention designed to improve school
belongingness and decrease symptoms of depression and loneliness among new college students. Participants were 438 first-year and transfer students
(232 treatment, 206 waitlist-control) at a medium-sized, 4years, predominantly White public university in the Southeastern United States. At
postintervention, the treatment group reported significant relative increases in school belonging and significant relative reductions in levels of
loneliness and depressive symptoms in comparison to waitlist-controls. Program effects were stronger for students from marginalized racial or ethnic
backgrounds, students from lower socioeconomic status households, and transfer students. Results are interpreted as suggesting the utility of
experiential, peer-support prevention programming to promote college students' well-being, particularly college students who hold identities that
are traditionally disadvantaged in this context. Copyright © 2022 The Authors. American Journal of Community Psychology published by Wiley
Periodicals LLC on behalf of Society for Community Research and Action.
American Journal of Community Psychology, 70(3
-4) : 314-326
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Choi, J., Kim, J. H., Park, M., Lee, H.
J.
Many
individuals are suffering from depression, and various improvements are being proposed. This study was conducted on young people diagnosed with
depression and aimed to assess the effects of flavonoid-rich orange juice on the major depressive disorder (MDD) using a randomized controlled trial.
In all, 40 young men and women with MDD aged 18-29 years were randomly assigned to a flavonoid-rich orange juice group (FR group) and a flavonoid-low
orange cordial group (FL group). The subjects drank the corresponding juice three times a day (190 mL per bottle) for 8 weeks. The blood BDNF,
zonulin, and claudin-5 levels significantly increased (p < 0.0001, p < 0.01, and p < 0.05, respectively) in the FR group, and the fatty acid binding
protein 2 (FABP2) level was significantly decreased (p < 0.0001) in the FR group after the juice intervention. The FABP2, LPS, and valeric acid
levels were negatively correlated with the abundance of Butyricicoccus pullicaecorum, which was higher in the FR group. Orange juice intake improved
depressive symptoms in young adults with MDD in the FR group. This B. pullicaecorum can be a potential biomarker for clinical improvement in young
adults with MDD patients.
Nutrients, 15(1) : 28
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Vitamins and supplements
Chiodelli, R., Jesus, S. N., Mello, L. T.
N., Andretta, I., Oliveira, D. F., Costa, M. E. S., Russell, T.
Rates of mental health issues have
been increasing among university students. This study investigates the effects of the Interculturality and Mindfulness Program (PIM) on academic
students on mindfulness, emotional regulation, depression, anxiety, stress, life satisfaction, optimism, positive solitude, and loneliness. A quasi-
experimental research was conducted, with pre- and post-test comparative measurements in three groups: in-person (IG), synchronous online (OG), and
passive control (CG). A diverse group of students (n = 150; mean age = 25.4 +/- 8.31) participated from two universities in Portugal. When compared
to the CG, both active groups (IG and OG) demonstrated a beneficial interaction effect in acceptance, positive solitude, optimism, and mindfulness.
The IG demonstrated a positive interaction effect in awareness and satisfaction with life, whereas the OG indicated a favorable interaction effect in
impulse. When analyzing the intra-group effects, both active groups presented a significant improvement in stress, emotion regulation, mindfulness,
positive solitude, and optimism. The OG demonstrated an improvement in awareness and loneliness. The main limitations of this research are that
students were not randomly assigned, and groups were heterogeneous in nationality, education level, and sex. Nonetheless, PIM has indicated
beneficial results in both IG and OG, and is a promising intervention for the prevention of mental health issues (e.g., stress, difficulties in
emotional regulation, and loneliness), as well as for the promotion of well-being (e.g., positive solitude, mindfulness, life satisfaction, and
optimism).
European Journal of Investigation in Health Psychology & Education, 12(10) : 1500-
1515
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Controlled clinical trials
-
Stage: Universal prevention
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Other Psychological Interventions, Mindfulness based
therapy, Technology, interventions delivered using technology (e.g. online, SMS)
Cheung, T., Ho, J., Fong-Leung, S., Yeung, J., Kranz,
G., Fong, K., Cheng, C., Xiang, Y. T., Beisteiner, R.
Introduction: Depression is a
debilitating disorder affecting individuals' level of bio-psychosocial functioning across different age groups around the globe. The recent
development of a new NIBS called Transcranial Pulse Stimulation (TPS), also known as low-intensity extracorporeal shock wave therapy (Li-ESWT), has
been proven effective for only a 2-week treatment of 35 patients with Alzheimer's disease (AD). Patients' cognition and memory have shown
significant improvement which lasted up to 3 months. However, there is a lack of scientific evidence on the efficacy of this TPS intervention on
other psychiatric population such as Major Depressive Disorder (MDD), which is increasingly prevalent in Hong Kong and nationwide especially during
the COVID-19 pandemic. Nonetheless, there is no trial evaluating the efficacy of TPS on other neuropsychiatric disorders. This gave us the impetus to
evaluate the efficacy of TPS on young adults with Major Depressive Disorder (MDD) in Hong Kong. Method(s): In this single-blinded, randomized
controlled trial, participants had a confirmed clinical diagnosis of MDD, recruited from the community, NGOs and private enterprise. The intervention
was a 2-week TPS treatment comprised six 30-min TPS sessions, delivered by trained mental health professionals. A total of 30 participants were
recruited and randomized into either the TPS group or the Waitlist Control (WC) group. Randomization was stratified by gender and age by an
independent statistician on a 1:1 ratio. Our primary outcome was determined by whether participants' depressive symptom severity demonstrated
significant reduction, compared with the WC group, using the Hamilton Depression Rating Scale-17 (HDRS17). This trial is registered with
Clin.Trials.gov, number NCT05006365. Result(s): We recruited 30 participants from 1 August to 31 Oct 2021. They were between 18-54 years old and were
predominantly female (73%), ethnically Chinese. There was a significant group x time interaction (F(1, 28) = 818.8, p <.001). Compared with the WC
group, there was a significant reduction in the depressive symptom severity in the TPS group (mean difference = -6.60, p = 0.02, Cohen's d = -0.93).
Results showed a significant intervention effect and the effect was large. Conclusion(s): TPS is safe and effective to reduce depressive symptoms
among young individuals with MDD in this trial. Therefore, TPS may be considered as a top treatment option for neuropsychiatric disorders in clinical
psychiatry. Funding(s): This trial is funded by the Departmental General Research Fund, the Hong Kong Polytechnic University, Hong Kong SAR, China.
Copyright © 2022
Clinical
Neurophysiology, 141(Supplement) : S30
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Other biological interventions
Chen, Y., Liu, X., Chiu, D. T., Li, Y., Mi, B., Zhang, Y., Ma,
L., Yan, H.
Aims: Problematic social media use is increasing in China and could be a risk factor for depression. We investigated cross-sectional
associations between problematic social media use and depressive outcomes among Chinese college students with potential mediation by perceived social
support, social media violence, and loneliness. Thereafter, we evaluated the effectiveness of a one-month group counseling intervention in reducing
depressive symptoms related to social media addiction. Method(s): Depressive symptoms, social media addiction, perceived social support, social media
violence, and loneliness were self-reported among 21,000 college students in Shaanxi province, China. A randomized controlled trial was designed
based on the results of the observational study and Satir Transformational Systemic Therapy (STST) among 60 college students assigned to intervention
(N = 30) or control/no treatment (N = 30). Self-administered surveys were completed at baseline (T1), at the end of the 1-month intervention (T2),
and at 2-month follow-up post-intervention (T3). Result(s): After controlling for relevant covariates, more problematic social media use was
associated with more depressive symptoms (beta = 0.18, p < 0.001) and depression (OR = 1.08, 95% CI: 1.075, 1.092). Multiple mediation analyses found
that perceived social support, social media violence, and loneliness significantly mediated associations between problematic social media use and
depressive symptoms (model fit: RMSEA = 0.065, GFI = 0.984, CFI = 0.982). Bootstrapping revealed significant indirect effects of problematic social
media use on depressive symptoms through the mediators named above (0.143, 95% CI: 0.133, 0.156). The subsequently informed intervention
significantly reduced depressive symptoms at T2 (mean difference: -12.70, 95% CI: -16.64, -8.76, p < 0.001) and at T3 (mean difference: -8.70, 95%
CI: -12.60, -4.80, p < 0.001), as well as levels of social media addiction, perceived social support, social media violence, and loneliness.
Conclusion(s): Problematic social media use is a risk factor for depressive outcomes among Chinese college students, and perceived social support,
social media violence, and loneliness mediate this association. STST-based group counseling may reduce depressive symptoms related to high social
media usage in this population. Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
International Journal of Environmental Research and Public Health, 19(9) (no
pagination) :
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Other Psychological Interventions, Technology, interventions delivered using technology (e.g. online, SMS)
Chen, H., Hu, X., Gao, J., Han, H., Wang, X., Xue, C.
Background: Adolescence is a period of high incidence for depression. However, there is a limited
treatment option for the adolescent depression. For treatment-resistant major depressive disorder, HF-rTMS of the left dorsolateral prefrontal cortex
(DLPFC) appears therapeutically effective. The aim of the study is to explore the early effects of repetitive transcranial magnetic stimulation in
combination with sertraline in adolescents with first-episode major depressive disorder. Method(s): A total of 100 teenage patients with first-
episode depression were randomly divided into the study groups. Both groups were treated with sertraline. In addition, the study group was treated
with ten sessions of add-on rTMS. The control group was given sertraline only. The depressive symptom and cognitive function were assessed by the
Hamilton depression rating scale 17 version (HAMD-17), Children's Depression Rating Scale-Revised (CDRS-R), Integrated visual and auditory
continuous performance test (IVA-CPT), and THINC-it. Result(s): The number of early improvers after 2 weeks of treatment in the study group was
statistically significant higher compared to the control group (95.83% vs 73.47%, chi2 = 9.277, P = 0.002). There was significant
difference observed in responder rates (62.50% vs. 28.57%, chi2 = 11.262, P = 0.001) or in remission rates (31.25% vs. 6.12%,
chi2 = 10.130, P = 0.001) between the two groups at 4 weeks. The score of HAMD-17 and CDRS-R in the study group were significantly lower
than the control group (Fgroup = 12.91 vs 10.21, P < 0.05). Attention Quotient (listening, visual and full-scale) attention quotient of
IVA-CPT in the study group were higher than those in the control group after treatment, and the differences were statistically significant(P < 0.05).
The study group showed higher score in Spotter than the control group after treatment (P < 0.05). Discussion(s): This is the most extensive blinded,
randomized clinical study to date examining the efficacy of 10-Hz add-on rTMS for first-onset adolescent depression. Our results support that add-on
rTMS accelerates the efficacy of the antidepressants, improving the depressive symptoms and cold cognitive function in first-episode adolescent
depression. Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [ChiCTR2100048534]. Copyright © 2022 Chen, Hu, Gao, Han, Wang and
Xue.
Frontiers in Psychiatry, 13 (no pagination) :
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Selective serotonin reuptake inhibitors (SSRIs), Antidepressants
(any), Transcranial magnetic stimulation
(TMS)
Chawla, G., Azharuddin, M., Ahmad, I., Hussain, M. E.
Objectives: To determine the effects of whole-body vibration (WBV) training on depression, anxiety, stress, and quality of life (QoL) in
college students. Method(s): The participants comprised college students who led physically inactive lifestyles as revealed by their Medical Outcomes
Study Form 36 (SF-36) scores, and with elevated scores of Depression Anxiety Stress Scale (DASS) test. They were randomly allocated to two groups of
15 each: (a) the WBV group (male = 3, female = 12) and (b) the exercise group (male = 6, female = 9). The participants in the WBV group performed
prescribed exercises while they stood on a vibrating platform whereas those in the exercise group performed the same exercises but without the
vibrating platform. After four weeks of twice-a-week training, DASS and SF-36 were measured. The pre-and post-scores were compared between the
groups. Result(s): Depression (p < 0.001), anxiety (p < 0.001), and stress (p < 0.001) were found to reduce significantly for the WBV group compared
to the exercise group. There was also significant within-group improvement in all the components of SF-36 (p < 0.040). Conclusion(s): Exercising on
the WBV platform may reduce depression, anxiety, and stress in college students and improve their overall QoL. Copyright © 2022, Oman Medical
Specialty Board. All rights reserved.
Oman Medical
Journal, 37(4) :
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Physical activity, exercise, Other complementary & alternative
interventions
Chang, T. F. H., Ley, B. L., Ramburn, T. T., Srinivasan, S., Hariri,
S., Purandare, P., Subramaniam, B.
College students experienced increased stress and anxiety during
the COVID-19 pandemic. This study evaluated the effect of brief online Isha Upa Yoga modules on undergraduates' mental health and well-being.
Randomized control trial (RCT) with waitlist control crossover (N=679). The intervention group was instructed to learn and practice the modules daily
for 12weeks. At the end of the 4-week RCT, the control group was instructed to learn and practice the modules for the remaining 8weeks. Primary
outcomes included stress and well-being. Secondary outcomes included anxiety, depression, resilience, positive affect and negative affect. Linear
mixed-effects models were used for analyses. Isha Upa Yoga significantly reduced stress (Group [intervention, control]xTime [baseline, Week 4]
interaction, p=.009, d=.27) and increased well-being (GroupxTime interaction p=.002, d=.32). By the study's end, the intervention and control groups
experienced significant improvements in well-being (p<.001, p<.001), stress (p<.001, p<.001), anxiety (p<.001, p<.001), depression (p<.001, p=.004),
positive affect (p=.04, p<.001), and negative affect (p<.001, p<.001). Online Isha Upa Yoga shows promise for mitigating the pandemic's negative
impact on undergraduates' mental health and improving their well-being. Copyright © 2022 The International Association of Applied Psychology.
Applied Psychology: Health and well-being, 14(4) : 1408-
1428
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Service Delivery & Improvement, Mind-body exercises (e.g. yoga, tai chi, qigong), Physical activity, exercise, Technology, interventions delivered using technology (e.g. online, SMS)
Chandler,
L., Patel, C., Lovecka, L., Gardani, M., Walasek, L., Ellis, J., Meyer, C., Johnson, S., Tang, N. K. Y.
University is a time of significant transitions
during a young adult's life, with delayed and shortened sleep and poor mental health a common occurrence. This systematic review and meta-analysis
examined the effect of both multi-component and single-component sleep interventions on improving university students' sleep and mental health. Five
databases (MEDLINE, PsycINFO, Embase, CINAHL and Cochrane Library) were searched for relevant literature published until April 2022. Treatment
studies including university students aged 18-24 years, participating in a sleep intervention (multi-component, e.g., CBT-I, or single-component,
e.g., sleep hygiene) were eligible. Comparator groups were either active, i.e., alternative intervention, or passive, i.e., waitlist control or
treatment-as-usual, with study outcomes to include measures of sleep and mental health. Of 3435 references screened, 11 studies involving 5267
participants, with and without insomnia symptoms, were included for a narrative synthesis on intervention designs and methodology. Six studies
eligible for meta-analyses showed a moderate effect of sleep interventions in reducing sleep disturbance (SMD = -0.548 [CI: -0.837, -0.258]) at
post-treatment, alongside a small effect in improving anxiety (SMD = -0.226 [CI: -0.421, -0.031]) and depression (SMD = -0.295 [CI: -0.513, -0.077]).
Meta-regression examining study and intervention characteristics identified subpopulation (experiencing insomnia or not) as a significant moderator
for effects on sleep (p = 0.0003) and depression (p = 0.0063), with larger effects in studies with participants experiencing insomnia. Comparison
group type (active or passive) was also a significant moderator (p = 0.0474), with larger effects on sleep in studies using passive comparison
groups. Study type, delivery format, and intervention duration were not identified as significant moderators. At follow-ups, small but significant
effects were sustained for anxiety and depression. Protecting and promoting sleep amongst university students may help safeguard and advance mental
health. Copyright © 2022 The Authors
Sleep Medicine, 100 : 354-363
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Psychoeducation, Other Psychological Interventions, Other complementary & alternative
interventions
Cekic, Y., Ancel, G.
PURPOSE:
This study aims to investigate the effects of interpersonal relational role analysis (IRRA) on nursing students' depressive symptoms and coping
styles. DESIGN AND METHODS: This study was conducted with randomized controlled, pretest-posttest control group design, and follow-up test patterns
(n=10). FINDINGS: As a result, IRRA had a positive effect on nursing students' depressive symptoms and coping styles. PRACTICE IMPLICATIONS:
Psychiatric nurses and other mental health professionals can readily use IRRA to help reduce depressive symptoms in groups with mild to moderate
depressive symptoms and to develop effective styles to cope with stress. Copyright © 2021 Wiley Periodicals LLC.
Perspectives in Psychiatric Care, 58(4) : 1587-1598
- Year: 2022
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Castro-Camacho, L., Diaz, M. M., Barbosa,
S.
Given the high prevalence of
emotional disorders among college students, its high social, emotional and economic costs, and a large treatment gap, we designed and evaluated a
preventive group intervention based on the Unified Protocol for the transdiagnostic treatment of emotional disorders (UP; Barlow et al., 2011). A
total sample of 128 college students in a state university in Bogota (Colombia) was recruited for this quasi-experimental study with three assessment
points: pre-treatment, post-treatment, and three-month follow-up. Participants were included in the control or intervention conditions based on non-
random assignement. At the end of the intervention, group analysis suggested significant declines in transdiagnostic risk factors and neurotic
temperament and gains in mindfulness, perceived control, and emotional dysregulation. Significant declines were found also for emotional variables
such as stress, anxiety, and depression. These results suggest that a preventive intervention based on the Unified Protocol may have a significant
impact on several transdiagnostic risk factors and emotional variables making it a promising prevention and mental health promotion program for
college students. Since this is the first Colombian study on the matter, its replication and the use of larger and more diverse samples are
recommended for future research. (PsycInfo Database Record (c) 2022 APA, all rights reserved)
Journal of Behavioral and
Cognitive Therapy, 32(2) : 111-123
- Year: 2022
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Controlled clinical trials
-
Stage: Universal prevention
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT)