Disorders - depressive disorders
Cuijpers, P., Miguel, C., Harrer, M., Plessen, C. Y., Ciharova, M., Papola, D., Ebert, D., Karyotaki, E.
BACKGROUND: Over the past 16 years, we have developed
a 'Meta-analytic Research Domain' (MARD) of all randomized trials of psychological treatments of depression. A MARD is a living systematic review
of a research field, that cannot be otherwise covered by one (network) meta-analysis and includes multiple PICOs. In this paper we give an overview
of the findings of this MARD.\rMETHODS: A narrative review of the results of the 118 meta-analyses on psychotherapies for depression that were
published within our MARD.\rRESULTS: Most research has been conducted on cognitive-behavioral therapy (CBT), but several other psychotherapies are
also effective, with few differences between therapies. They can be effectively delivered in individual, group, telephone and guided self-help format
and are effective in many different target groups and across different age groups, although the effects are significantly smaller in children and
adolescents. Psychotherapies have comparable effects as pharmacotherapy at the short term but are probably more effective at the longer term.
Combined treatment is more effective than either psychotherapy or pharmacotherapy alone at the short, but also at the longer term.\rLIMITATIONS: We
did not summarize all published meta-analyses (protocols, methodological studies) and have not compared our results to those found in other meta-
analyses on comparable subjects.\rCONCLUSION: Psychotherapies can contribute considerably to a reduction of the disease burden of depression. MARDs
are an important next step in the aggregation of knowledge from randomized controlled trials in psychological treatments of depression as well as in
other healthcare sectors.
, 335 : 141-
151
- Year: 2023
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Interpersonal therapy (IPT), Problem solving therapy (PST), Supportive
therapy, Acceptance & commitment therapy
(ACT)
Cuijpers, P., Karyotaki, E., Ciharova, M., Miguel, C., Noma, H., Stikkelbroek, Y., Weisz, J. R., Furukawa, T. A.
Meta-analyses show that
psychotherapies are effective in the treatment of depression in children and adolescents. However, these effects are usually reported in terms of
effect sizes. For patients and clinicians, it is important to know whether patients achieve a clinically significant improvement or deterioration. We
conducted such a meta-analysis to examine response, clinically significant change, clinically significant deterioration and recovery as outcomes. We
searched four bibliographic databases and included 40 randomised trials comparing psychotherapy for youth depression against control conditions. We
used a validated method to estimate outcome rates, based on means, standard deviation and N at baseline and post-test. We also calculated numbers-
need-to- treat (NNT). The overall response rate in psychotherapies at 2 (+/-1) months after baseline was 39% (95% CI: 34-45) and 24% (95% CI: 0.19-
28) in control conditions (NNT: 6.2). The difference between therapy and control was still significant at 6-12 months after baseline (NNT=7.8).
Clinically significant improvement was found in 54% of youth in therapy, compared with 32% in control groups (NNT=5.3); clinically significant
deterioration was 6% in therapy, 13% in controls (NNT=5.1); recovery was 58% in therapy, 36% in controls (NNT=3.3). Smaller effects were found in
studies with low risk of bias. Psychotherapies for depression in youth are effective compared to control conditions, but more than 60% of youth
receiving therapy do not respond. More effective treatments and treatment strategies are clearly needed. Trial registrationhttps://osf.io/84xka.
Copyright © 2021, The Author(s).
European Child and Adolescent Psychiatry, 32(1) : 177-
192
- Year: 2023
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Family therapy, Interpersonal therapy (IPT), Problem solving therapy (PST), Supportive
therapy
Clements, Z. A., Riggle, E.
D., Rostosky, S. S.
Transgender people report high levels of discrimination, prejudice, stigma-related anxiety and depression, and suicidality. In socially,
politically, and religiously conservative areas, emphasis on traditional gender roles may lead to heightened levels of stigma-related stress and
anxiety in transgender people and pose additional challenges to the development of positive transgender identities. Using a pre-/posttest
experimental design, we evaluated an online resource aimed at increasing positive identity and psychological well-being (PWB) in young adult
transgender individuals living in the Southeast and Midwest United States. Participants, ages 18-26, were randomized into two groups to watch either
a video about positive transgender identity (intervention; n = 24) or a video with general information about lesbian, gay, bisexual, trans, queer
people (control; n = 14). Both groups completed preintervention and 2-week post measures of positive identity and PWB. One-way analysis of variance
of pre-post difference scores suggested that the intervention group reported significantly increased community connectedness, positive affect, and
positive relations with others, and significantly lowered depressive symptom scores compared to the control group. Findings suggest that brief online
interventions may be useful in supporting emotional health in transgender people; however, additional community supports may be crucial to positive
identity development. (PsycInfo Database Record (c) 2023 APA, all rights reserved) Impact Statement Transgender young adults in the Southeast and
Midwestern United States watched a brief general video about LGBTQ people or an intervention video highlighting positive aspects of transgender and
nonbinary identities. Compared to the group that watched the general video, the group that watched the positive identity video reported lower
depressive symptom scores and more positive feelings 2 weeks later. This study suggests brief, strengths-based, accessible interventions for
transgender individuals that may help facilitate some aspects of psychological well-being. (PsycInfo Database Record (c) 2023 APA, all rights
reserved)
Professional Psychology: Research and Practice, : No Pagination
Specified
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions
Cheung, K., Ma, K. Y., Tsang, H., Leung, N. H., Lui, K. Y., Ho, S. W.
Background: University students are identified as a
high-risk group for mental health problems. Artworks have been found effective in enhancing individuals' mental well-being in different populations,
but none have been conducted on university students. This study was to address this research gap to determine the feasibility and estimate the
preliminary effects of Zentangle and Pastel Nagomi on the mental well-being of undergraduate students during the COVID-19 pandemic.\rMethod: This was
a 3-arm randomized controlled trial, with 33 undergraduates allocated to two 8-week artworks (Zentangle or Pastel Nagomi Art group) and a control
group. Data were collected at baseline, and weeks 4, 6, 8, and 12. Focus group interviews were conducted at the 12-week follow-up.\rResults: The
consent and attrition rates were 80.5 and 6.06%, respectively. The attendance rate ranged from 83.3 to 100%. Compared with the control group, the
Pastel Nagomi art group had a significant improvement in retaining positive affect at week 6. This retention could be further observed at week 12.
Moreover, the Zentangle group had a significant increase in positive affect at week 4, with better retention at week 12. In addition, the within-
group analyses showed that the Pastel Nagomi art group had significantly decreased negative affect at weeks 6 and week 12; and the Zentangle group
had significantly decreased depression at week 8. The qualitative findings suggested that the intervention resulted in the participants enjoying the
artwork process, and being proud of their artwork and personal growth.\rLimitation: The study included an imbalance number of online vs. face-to-face
sessions, and repeated measures may have affected the results.\rConclusion: The study suggests that both artworks are effective in improving
undergraduates' mental well-being and that it is feasible to conduct future large-scale studies (263 words).
, 14 : 1132923
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Creative expression: music, dance, drama, art
Chen, S., Xu, T.
Background. Depression is a common psychiatric disease, which has become one of the main causes of the loss of healthy life
years. According to the survey, up to 50% of the patients with depression are school students. Depression mainly depends on drug therapy,
psychological intervention and physical therapy. In recent years, exercise therapy has become an economical and environmentfriendly intervention mode
for depression due to its advantages of high compliance and few side effects. The teaching of theoretical mechanics can mobilize students'
enthusiasm for learning, promote their deep thinking and arouse their curiosity to explore the unknown, and have a certain role in relieving
students' mental pressure. Therefore, based on theoretical mechanics teaching, the study used exercise therapy to intervene in students'
depression, aiming to explore effective methods to improve students' depression, and explore the changes in neurobiological mechanism of exercise
intervention combined with theoretical mechanics teaching in the treatment of depression. Subjects and Methods. 60 students suffering from depression
were randomly selected and divided into three groups, 20 students in each group. In group A, exercise combined with theoretical mechanics teaching
was used for the intervention treatment of students with depression. In group B, only theoretical mechanics teaching was used for intervention
treatment, while in group C, no intervention treatment was used. The three groups of experiments were performed with the same exercise intensity,
exercise frequency, and exercise volume. Then record and sort out the main neurobiological mechanisms such as nerve cells and neurotransmitters that
have changed during the treatment of depression. The experiment lasted for 12 weeks. In addition, the experiment used literature, observation and
other experimental methods to collate and analyze data information. Results. The study found that exercise combined with theoretical mechanics
teaching has the best performance effect in treating students' depression. The intervention intensity is usually 50% - 85% of the maximum heart
rate, and the recommended exercise frequency is 3-5 times/week. The neurobiological mechanism of exercise intervention on students' depression based
on theoretical mechanics teaching is shown in Figure 1 below. As shown by the arrow in Figure 1, it has a promoting effect. According to research,
the neurobiological mechanism of exercise combined with theoretical mechanics teaching in the treatment of depression is mainly manifested in
regulating cytokine production, mediating microRNA expression, increasing neurotransmitter release, maintaining mitochondrial function, and reducing
apoptosis of hippocampal neurons. Conclusions. This study verified that exercise intervention combined with theoretical mechanical therapy has a
certain relieving effect on students' depression. At the same time, it was found in this treatment process that the neurobiological mechanism of
exercise combined with theoretical mechanics in the intervention of depression was mainly to regulate the expression of cytokines and mediating
microRNA, release of neurotransmitters, inhibit the inflammatory pathway, maintain the mitochondrial function, and reduce the apoptosis of
hippocampal neurons.
CNS Spectrums, 28(Supplement 1) : S14-S15
- Year: 2023
- Problem: Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention), Disorder established (diagnosed disorder)
-
Treatment and intervention: Complementary & Alternative
Interventions (CAM), Physical activity, exercise
Chen, D., Cobb, M., Alexandria,
S., Sajwani, A., Diskin, R., Muldoon, A., Kuhns, L., Garofalo, R.
Purpose: Young sexual minority men (YSMM) experience mood and anxiety disorders
at 2-3 times the rate of heterosexual young men (Shearer et al., 2016). Mental health disparities in YSMM are attributable to minority stress (Meyer,
2003), whereby YSMM experience stressors induced by a hostile, homophobic culture which increases vulnerability to depression and anxiety. Evidence-
based mental health treatments have been culturally adapted to be LGBTQ-affirming (Pachankis et al., 2022); however, YSMM face many barriers to
accessing face-to-face care, including cost, privacy concerns, and stigma related to sexual identity. To address these barriers, we developed TODAY!,
a 10-week, culturally-tailored, app-based intervention and coaching protocol drawing on concepts from transdiagnostic CBT integrated with minority
stress considerations (Fleming et al., 2017). The goal of this pilot study was to evaluate the feasibility, acceptability, and preliminary efficacy
of TODAY! on improving symptoms of depression and anxiety in YSMM in a small randomized controlled trial. Method(s): YSMM ages 14-24 were recruited
through an adolescent and young adult medicine clinic, social media, and a registry of past research participants. Eligible participants were
randomized to receive either TODAY! or community referrals (control condition). Outcomes were feasibility of recruitment and retention, acceptability
of the intervention, and preliminary efficacy. Mixed effects models were used to evaluate the effect of TODAY! on depression (via PHQ-9) and anxiety
symptoms (via GAD-7). Result(s): Of 194 individuals screened, 98 were ineligible due to age, residence, gender identity, sex assigned at birth, or
sexual orientation/identity. Of 96 eligible individuals, 44 completed baseline assessments and 18 were ineligible due to subthreshold
depression/anxiety symptoms, concurrent mental health treatment, or co-occurring mental health conditions considered too severe to benefit from
TODAY! Thus, 26 individuals were eligible for randomization. Of these, 22 were randomized and 18 participated. Regarding retention, 100% completed
the phone assessment and 94% completed the online assessment at 5-weeks, 100% completed the phone assessment and 88% completed the online assessment
at 10-weeks, and 86% completed the phone and online assessments at 22-weeks. Participants randomized to intervention completed the Client
Satisfaction Questionnaire (range 10-40; higher scores = greater satisfaction) at 5-weeks: M(SD) = 30.3 (7.6); 10-weeks: M(SD) = 26.7 (9.1); and 22-
weeks: M(SD) = 25.8 (11.15). Linear mixed effects models suggested TODAY! did not impact PHQ-9 (Point Estimate: 0.8 points [95%CI -2.4, 4.1]; p =
0.61) or GAD-7 scores (PE: 0.6 points [95% CI -4.1, 5.3]; p = 0.81) at 10-weeks, relative to control. However, TODAY! reduced PHQ-9 scores by 3.7
points (95%CI -0.5, -7.0; p = 0.03) relative to control at 5-weeks. Post-hoc examination of usage data suggests app use declines after the initial 5
weeks. Conclusion(s): TODAY! appears acceptable to YSMM and feasible to implement. However, preliminary efficacy findings suggest TODAY! content may
need further development to more effectively target depression and anxiety symptoms, and improve engagement and adherence over a 10-week treatment
course. Sources of Support: This work was supported by internal funding from the Potocsnak Family Division of Adolescent and Young Adult Medicine.
Copyright © 2022
Journal of Adolescent Health, 72(3 Supplement) : S14-
S15
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Other Psychological Interventions
Chen, B., Yang, T., Xiao, L., Xu, C., Zhu, C.
Background: Mobile mindfulness meditation (MMM) is a mindfulness meditation intervention implemented using mobile devices such as smartphones and
apps. MMM has been used to help manage the mental health of university students. Objective(s): This study aims to evaluate the effectiveness of MMM
on the mental health of university students in the areas of stress, anxiety, depression, mindfulness, well-being, and resilience. Method(s): We
conducted a systematic review and meta-analysis of the effectiveness of MMM on the mental health of university students. This study followed the
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. An electronic literature search was performed on PubMed, Web
of Science, EBSCO, Cochrane Library, and Embase databases, from inception to July 16, 2021. This study was conducted to identify studies that
reported the effects of MMM on the primary outcomes including stress, anxiety, and depression, and on the secondary outcomes including mindfulness,
well-being, and resilience. Two reviewers retrieved articles, evaluated quality, and extracted data independently. The methodological quality of the
selected studies was determined using the Cochrane criteria for risk-of-bias assessment. Standardized mean differences (SMDs) for continuous outcomes
and risk ratios for dichotomous outcomes were calculated. Sensitivity analyses and subgroup analyses were performed for results with high
heterogeneity. The RevMan version 5.3 was used to perform meta-analysis. Result(s): A total of 10 studies, including 958 university students, were
selected for this meta-analysis. Results of the primary outcome showed that the MMM groups were more effective than the control groups in decreasing
stress (SMD -0.41, 95% CI -0.59 to -0.23; P<.001) and alleviating anxiety (SMD -0.29, 95% CI -0.50 to -0.09; P=.004). However, there was no
difference between the MMM groups and the control groups in depression (SMD -0.14, 95% CI -0.30 to 0.03; P=.11). The use of either waitlist control
or traditional face-to-face intervention in the control group was identified as the source of heterogeneity. Specifically, the waitlist control
subgroup (SMD -0.33, 95% CI -0.53 to -0.13; P=.002) was superior when compared with the face-to-face subgroup (SMD 0.29, 95% CI -0.01 to 0.59;
P=.06). Results of the secondary outcome showed that the MMM groups were more effective than the control groups in enhancing well-being (SMD 0.30,
95% CI 0.11-0.50; P=.003) and improving mindfulness (SMD 2.66, 95% CI 0.77-4.55; P=.006). Whether commercial sponsorship was obtained was considered
as the source of heterogeneity. The \"without company support\" group (SMD 17.60, 95% CI 11.32-23.87; P<.001) was superior to the \"with company
support\" group (SMD 1.17, 95% CI -0.82 to 3.15; P=.25) in raising the level of mindfulness. However, there was no difference between the MMM and
control groups in resilience (SMD -0.06, 95% CI -0.26 to 0.15; P=.59). The evidence level of the results from the 10 studies was determined to be
moderate to low. Conclusion(s): MMM was an effective method to reduce stress and anxiety, and to increase the well-being and mindfulness of
university students. However, further studies are needed to confirm our findings. Trial Registration: PROSPERO International Prospective Register of
Systematic Reviews CRD42022303585; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=303585 Copyright ©Bin Chen, Ting Yang, Lei Xiao,
Changxia Xu, Chunqin Zhu.
Journal of Medical Internet Research, 25 (no pagination) :
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Systematic reviews
-
Stage: Universal prevention, At risk (indicated or selected prevention)
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Mindfulness based
therapy, Technology, interventions delivered using technology (e.g. online, SMS)
Charbonnier, E., Le Vigouroux, S., Puechlong, C., Montalescot,
L., Goncalves, A., Baussard, L., Gisclard, B., Philippe, A. G., Lespiau, F.
University students are a vulnerable population, and many recent studies show that anxiety, depressive symptoms, and academic burnout have
been on the increase since the beginning of the COVID-19 pandemic. These findings point to a need for interventions to reduce these difficulties. The
purpose of the present study was to assess the effects of 2 formats of an innovative program on students' mental health (anxiety, depressive
symptoms, and academic burnout), intolerance of uncertainty, learned helplessness, and learning. Our sample was composed of 105 university students,
recruited on a voluntary basis. They were divided into 3 groups: online intervention group (n=36), face-to-face intervention group (n=32), and
control group (n=37). The following variables were measured through online questionnaires: anxiety and depressive symptoms, academic burnout,
intolerance of uncertainty, learned helplessness, perceived social support, learning strategies, and beliefs. There were 2 assessments 10weeks apart
(ie, before and after the program in the case of the 2 intervention groups). We performed nonparametric analyses to run comparisons between the 2
assessment timepoints in each group. Results showed that participants in the 2 intervention groups had lower levels of learned helplessness and
intolerance of uncertainty at the end of the program. Furthermore, participants in the face-to-face group reported higher levels of perceived social
support, academic self-efficacy, and help-seeking strategies. The present study highlighted the benefits of our innovative program, especially its
face-to-face format.Clinical Trial - ID: NCT04978194.
Inquiry: a Journal of Medical Care Organization, Provision and
Financing, 60 : 469580231159962
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Controlled clinical trials
-
Stage: Universal prevention
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Other Psychological Interventions, Technology, interventions delivered using technology (e.g. online, SMS)
Chang, C., Palermo, E., Deswert, S., Brown, A., Nuske, H. J.
Mental health disorders are prevalent among college students and increasing in frequency and
severity. However, there is a significant gap between those who need treatment and those who engage in treatment. Given the documented efficacy of
financial incentives for promoting health behavior change and engagement in treatment, financial incentives may help, along with nonfinancial
behavioral incentives such as motivational messaging, gamification, and loss aversion techniques. We compared brief (28-day) use of two versions of a
behavioral economics-inspired digital mental health app, NeuroFlow: (1) the full app including financial incentives and nonfinancial behavioral
incentives (treatment group) and (2) a version of the app with nonfinancial behavioral incentives only (control group). In our intent-to-treat
analyses, in order to examine the primary outcome of app engagement, a one-way analysis of variance (ANOVA) (treatment vs. control) was conducted,
and to examine the secondary outcomes (depression, anxiety, emotion dysregulation, and wellbeing), a two-way repeated measures ANOVAs (treatment vs.
control x baseline vs. post-trial) were conducted. We found that there were no differences between treatment groups on app engagement or the change
in the mental health/wellness outcome measures. There was a main effect of timepoint on symptoms of anxiety and emotion dysregulation, such that
there were significantly lower self-reported symptoms at post-trial relative to baseline. Our results suggest that financial incentives in digital
mental health apps over and above nonfinancial behavioral incentives do not have an impact on app engagement or mental health/wellness outcomes.
Digital
Health, 9 : 20552076231170693
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: Universal prevention
-
Treatment and intervention: Service Delivery & Improvement, Psychological Interventions
(any), Cognitive & behavioural therapies (CBT), Mindfulness based
therapy, Technology, interventions delivered using technology (e.g. online, SMS), Other service delivery and improvement
interventions
Cao, P., Li, Y., An, B., Ye, L., Xu, Z.
Background: Repetitive Transcranial magnetic stimulation (rTMS) combined with
antidepressants benefited adults with depression while its efficacy and safety in children and adolescents with depression remain controversial.
Method(s): We searched PubMed, Embase, the Cochrane Library, Web of Science, CINAHL, LILACS, PsycINFO, CNKI, Wanfang Data Knowledge Service Platform,
a Chinese Biology Medical disc database, and relevant clinical registration databases for randomized controlled trials from their inception to
October 18, 2022. The efficacy of the treatment was assessed by changes in depression rating scale scores. Safety was assessed by the incidence of
adverse events. Heterogeneity was determined using the Cochrane Q statistics and I2 statistics. Publication bias was assessed by Egger's
test. Result(s): Eighteen studies from 10 datasets (1396 patients, 64.7 % female, age range from 8 to 24 years old). The pooled mean-endpoint scores
of the depression scale for rTMS combined with the antidepressant group were significantly lower than those of sham combined with the antidepressant
group both in two weeks (MD = -4.68, 95 % CI: [-6.66, -2.69]; I2 = 91 %; P < 0.05) and four weeks (MD = -5.53, 95 % CI: [-9.90, -1.16];
I2 = 98 %; P < 0.05). There were no differences in safety (OR = 0.64, 95 % CI: [0.20, 2.04]; I2 = 64 %; P = 0.45) and
acceptability between the two groups (3/70 vs 3/70). Limitation(s): Heterogeneity was found in this study due to the limited number of original
studies included. Conclusion(s): rTMS combined with antidepressants enhanced the efficacy of the antidepressant medication. The safety and
acceptability of the two groups were comparable. These findings may help guide future research and clinical practice. Copyright © 2023 The
Authors
, 336 : 25-34
- Year: 2023
- Problem: Depressive Disorders
- Type: Systematic reviews
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Selective serotonin reuptake inhibitors (SSRIs), Antidepressants
(any), Transcranial magnetic stimulation
(TMS)
Cai, H., Du, R., Song, J., Wang, Z., Wang, X., Yu, Y., Wang, Y., Shang, L., Zhang, J., Yang, K., Li,
W.
OBJECTIVE: Few studies on electroconvulsive therapy (ECT) investigate efficacy and safety on depressive adolescents with
strong suicidal ideation. Our study examined adolescents (aged 13-18 years) with major depressive disorder to explore ECT effectiveness in improving
suicidal ideation and depressive symptoms, as well as its impact on cognitive function.\rMETHODS: This nonrandomized controlled trial enrolled 183
adolescent patients suffering from major depressive disorder. The ECT group (n = 81) was treated with antidepressants and 8 rounds of ECT for 2
weeks. The control group comprised 79 patients treated with antidepressants only. Depressive symptoms, suicidal ideation, and cognitive functions
were assessed at baseline (pre-ECT) and at 2 and 6 weeks post-ECT.\rRESULTS: The ECT group showed significant improvements over control in suicidal
ideation from the end of treatment to 6 weeks after (P < 0.001). Depressive symptoms also improved (P < 0.001). Patients treated with ECT
demonstrated poorer performance in delayed memory, attention, and language, but these impairments were transient. Thus, ECT was generally safe in
adolescent patients with major depressive disorder.\rCONCLUSIONS: Our findings verified ECT as effective and safe for improving suicidal ideation and
depressive symptoms of adolescent patients with major depressive disorder. In addition, partially impaired cognitive function recovered gradually
after ECT.
Journal of ECT, 30 : 30
- Year: 2023
- Problem: Depressive Disorders, Suicide or self-harm behaviours (excluding non-suicidal self-harm)
- Type: Controlled clinical trials
-
Stage: Disorder established (diagnosed disorder)
-
Treatment and intervention: Biological Interventions
(any), Selective serotonin reuptake inhibitors (SSRIs), Antidepressants
(any), Electroconvulsive therapy (ECT)
Bruns, E. J., Lee, K., Davis, C., Pullmann, M. D., Ludwig, K., Sander, M., Holm-Hansen,
C., Hoover, S., McCauley, E. M.
Schools offer an advantageous setting for the prevention, early
identification, and treatment of mental health problems for youth. However, school mental health (SMH) services are typically not based on evidence
for effectiveness, nor are they efficiently delivered, with SMH practitioners (SMHPs) able to only treat a small number of students in need. The
current study evaluated the feasibility, acceptability, efficiency, and outcomes of a four-session assessment, engagement, problem-solving, and
triage strategy for SMHPs that aimed to improve efficiency while being based on elements of evidence-based care. The study, conducted in 15 US school
districts in three states, used stratified random assignment to assign 49 high schools and their participating SMHP(s) to either the Brief
Intervention for School Clinicians (BRISC; N=259 students) or services as usual (SAU; N=198 students). SMHPs implemented BRISC elements with adequate
to excellent fidelity and reported the strategy was feasible and well-aligned with presenting problems. Students assigned to BRISC reported
significantly greater engagement in SMH at 2 months and completion of SMH treatment by 6 months. BRISC-assigned SMHPs reported significantly greater
treatment completion after four sessions (53.4%) compared to SAU (15.4%). Students in the BRISC condition also reported significantly greater
reduction in problem severity as evaluated by the Youth Top Problems Assessment. No differences were found for anxiety or depression symptoms or
overall functioning. Results indicate that BRISC is a feasible early intervention and triage strategy that may aid in more efficient provision of SMH
services with no compromise to SMH effectiveness. Copyright © 2023. The Author(s).
, 24(4) : 701-714
- Year: 2023
- Problem: Anxiety Disorders (any), Depressive Disorders
- Type: Randomised controlled trials
-
Stage: At risk (indicated or selected prevention)
-
Treatment and intervention: Psychological Interventions
(any), Other Psychological Interventions